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| Thai / English name |
Part Used : ใบActivity : CYP3A4 INHIBITIONSolvent/Active Compound : Aqueous extracts (Darjeeling tea)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Aqueous extracts of bulk spices 25 mg/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Resut: Percent inhibition = 82.9+/-1.71
Part Used : ใบActivity : CYP3A4 INHIBITIONSolvent/Active Compound : Aqueous extracts (Earl Grey tea)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Aqueous extracts of bulk spices 25 mg/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Resut: Percent inhibition = 78.3+/-0.63
Part Used : ใบActivity : CYP3A4 INHIBITIONSolvent/Active Compound : Aqueous extracts (English breakfast tea)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Aqueous extracts of bulk spices 25 mg/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Resut: Percent inhibition = 84.0+/-1.54
Part Used : ใบActivity : CYP3A4 INHIBITIONSolvent/Active Compound : Aqueous extracts (English breakfast tea)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Aqueous extracts of bulk spices 25 mg/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Resut: Percent inhibition = 76.5+/-0.51
Part Used : ใบActivity : CYP3A4 INHIBITIONSolvent/Active Compound : Aqueous extracts (Orange Pekoe tea)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Aqueous extracts of bulk spices 25 mg/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Resut: Percent inhibition = 83.1+/-1.01
Part Used : -Activity : CYP3A4 INHIBITIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Ketoconazole*/Nizoral/Levoketoconazole/Panfungol/Ketoisdin/Orifungal M/Ketozole/Normocort/Ketoderm/Fungarest/Fungoral/Extina/Ketoconazolum/Brizoral/Kuric/Ketoconazol/Xolegel/Onofin K/Teryzolin/TerzolinDose/Conc.(drug) : -Result : PositiveRemark : The IC50/IC25 ratios for the inhibiting herbal remedies ranged from 2.15 to 2.67, indicating similar inhibition profiles of the herbal inhibitors of CYP3A4. Garlic and Natto K2 were classified as non-inhibitors. Although Agaricus, noni juice, mistletoe and green tea inhibited CYP3A4 metabolism in vitro, clinically relevant systemic or intestinal interactions with CYP3A4 were considered unlikely, except for a probable inhibition of intestinal CYP3A4 by the green tea product.Note : Testosterone was used as a substrate and ketoconazole as a positive quantitative inhibition control.
Part Used : -Activity : CYP3A4 INHIBITIONSolvent/Active Compound : KaempferolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark :Note : Three coumarins and 12 flavonoids significantly suppressed CYP3A4 or CYP2C9 activities. Lineweaver-Burk plot analysis indicated that apigenin and its dimer amentoflavone and imperatorin displayed a mixed type of inhibition on CYP3A4 or CYP2C9. Among the inhibitors, amentoflavone was the most potent inhibitor of CYP3A4 and CYP2C9 activities with IC50 values of 0.07 and 0.03 micromolar, respectively. The Ki value of amentoflavone was significantly lower than that of the CYP2C9 inhibition positive control sulfaphenazole.
Part Used : -Activity : CYP3A4 INHIBITIONSolvent/Active Compound : MyricetinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark :Note : Three coumarins and 12 flavonoids significantly suppressed CYP3A4 or CYP2C9 activities. Lineweaver-Burk plot analysis indicated that apigenin and its dimer amentoflavone and imperatorin displayed a mixed type of inhibition on CYP3A4 or CYP2C9. Among the inhibitors, amentoflavone was the most potent inhibitor of CYP3A4 and CYP2C9 activities with IC50 values of 0.07 and 0.03 micromolar, respectively. The Ki value of amentoflavone was significantly lower than that of the CYP2C9 inhibition positive control sulfaphenazole.
Part Used : ใบActivity : CYP3A4 INHIBITIONSolvent/Active Compound : green tea extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 25 microgram/mlDuration : 5 minutesType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : - Details of the standardized Green tea extracts: 99.61% Tea polyphenols, 65.38% EGCG, 82.79% Catechins, 1.17% Caffeine, 3.98% Water, 0.18% Sulfated ash. - Results: The degree of CYP3A4 inhibition of Ginkgo biloba was 93.8% and IC50 values of that inhibit CYP3A4-mediated metabolism of midazolam = 9.96 microgram/ml, 95% Cl: 5.41-18.3.Note : The effects of complementary and alternative medicine (CAM) on CYP3A4-mediated metabolism of midazolam and docetaxel were determined in human liver microsomes (HLM), using liquid-chromatography coupled to tandem mass spectrometry (LC-MS/MS).
Part Used : ใบActivity : CYP3A4 INHIBITIONSolvent/Active Compound : green tea extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 microgram/mlDuration : 30 minutesType of interaction : PharmacokineticsInteraction with drug : Docetaxel*/TaxotereDose/Conc.(drug) : -Result : PositiveRemark : - Details of the standardized Green tea extract: 99.61% Tea polyphenols, 65.38% EGCG, 82.79% Catechins, 1.17% Caffeine, 3.98% Water, 0.18% Sulfated ash. - Results: The degree of CYP3A4 inhibition of Ginkgo biloba was 90.9% and IC50 values of that inhibit CYP3A4-mediated metabolism of docetaxel = 42.3 microgram/ml, 95% Cl: 36.2-49.4.Note : The effects of complementary and alternative medicine (CAM) on CYP3A4-mediated metabolism of midazolam and docetaxel were determined in human liver microsomes (HLM), using liquid-chromatography coupled to tandem mass spectrometry (LC-MS/MS).
