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THEACEAE Camellia sinensis (L.) Kuntze

Synonym

THEACEAE Thea sinensis L.
THEACEAE Camellia sinensis (L.) Kuntze var. assamica (Mast.) Kitam.

Thai / English name

ชา*

[1-4] of 4 article(s) found

หน้า 1

[1] IN VITRO INHIBITION OF HUMAN CYTOCHROME P450-MEDIATED METABOLISM OF MARKER SUBSTRATES BY NATURAL PRODUCTS.
FOSTER BC,VANDENHOEK S,HANA J,ET AL.
PHYTOMEDICINE 2003 Vol.10(),334-42 $11159 [Full]

Part Used : ใบ
Activity : CYP2D6 INHIBITION

Solvent/Active Compound : Aqueous extracts (Darjeeling tea)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Aqueous extracts of bulk spices 25 mg/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Resut: Percent inhibition = 75.7+/-1.45

Part Used : ใบ
Activity : CYP2D6 INHIBITION

Solvent/Active Compound : Aqueous extracts (Earl Grey tea)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Aqueous extracts of bulk spices 25 mg/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Resut: Percent inhibition = 90.6+/-0.60

Part Used : ใบ
Activity : CYP2D6 INHIBITION

Solvent/Active Compound : Aqueous extracts (English breakfast tea)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Aqueous extracts of bulk spices 25 mg/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Resut: Percent inhibition = 88.7+/-1.74

Part Used : ใบ
Activity : CYP2D6 INHIBITION

Solvent/Active Compound : Aqueous extracts (Irish breakfast tea)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Aqueous extracts of bulk spices 25 mg/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Resut: Percent inhibition = 90.1+/-0.26

Part Used : ใบ
Activity : CYP2D6 INHIBITION

Solvent/Active Compound : Aqueous extracts (Orange Pekoe tea)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Aqueous extracts of bulk spices 25 mg/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Resut: Percent inhibition = 92.6+/-1.72

[2] GREEN TEA (CAMELLIA SINENSIS) EXTRACT DOES NOT ALTER CYTOCHROME P450 3A4 OR 2D6 ACTIVITY IN HEALTHY VOLUNTEERS.
DONOVAN JL,CHAVIN KD,DE VANE CL,ET AL.
DRUG METAB DISPOS 2004 Vol.32(9),906-8 271181 [Abstract]

Part Used : ไม่ระบุ
Activity : CYP2D6 INHIBITION

Solvent/Active Compound : decaffeinated green tea

Type of experiment : human
Type of animal : -

Type of study : Open trial

N(Total) : 11
N(Treatment) : 11

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 4 DGT capsules/day (DGT capsule contained 211+/-25 mg of green tea catechins and <1 mg of caffeine)

Duration : 14 days
Type of interaction : Pharmacokinetics

Interaction with drug : Dextromethorphan*/Dextromethorfan/Dextromorphan
Dose/Conc.(drug) : 30 mg

Result : Negative

Remark : The DMR was 0.053+/-0.045 at baseline and 0.041+/-0.032 after DGT supplementation (P >0.05).

Note : Data incomplete Subject total: healthy volunteers - Results indicate that DGT is unlikely to alter the disposition of medications primarity dependent on the CYP2D6 or CYP3A4 pathways of metabolism. Abbreviation decaffeinated green tea : DGT dextromethorphan metabolic ratios: DMRS alprazola: ALPZ

[3] EFFECTS OF CONTINUOUS INGESTION OF GREEN TEA OR GRAPE SEED EXTRACTS ON THE PHARMACOKINETICS OF MIDAZOLAM.
NISHIKAWA M,ARIYOSHI N,KOTANI A,ET AL.
DRUG METABOLISM AND PHARMACOKINETICS 2004 Vol.19(4),280-9 271495 [Abstract]

Part Used : ไม่ระบุ
Activity : CYP2D6 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : 1 weeks
Type of interaction : Pharmacokinetics

Interaction with drug : Midazolam*/Versed/Dormicum
Dose/Conc.(drug) : -

Result : Positive

Remark : Strong inhition of these CYP activities was found by the addn. of green tea ext. or grape seed ext. in vitro.

Note : Data incomplete

[4] EFFECTS OF REPEATED GREEN TEA CATECHIN ADMINISTRATION ON HUMAN CYTOCHROME P450 ACTIVITY.
CHOW H-H,SHERRY,HAKIM IA,ET AL.
CANCER EPIDEMIOL BIOMARKERS PREV 2006 Vol.15(12),2473-6 347694 [Abstract]

Part Used : -
Activity : CYP2D6 INHIBITION

Solvent/Active Compound : green tea catechins, epigallocatechin gallate (EGCG)

Type of experiment : human
Type of animal : -

Type of study : non specified

N(Total) : 42
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 800 mg epigallocatechin gallate (EGCG) daily

Duration : 4 weeks
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Four weeks of green tea catechin intervention did not alter the phenotypic indexes of CYP1A2, CYP2D6, and CYP2C9, but resulted in a 20% increase (P=0.01) in the area under the plasma buspirone concn.-time profile, suggesting a small reduction in CYP3A4 activity.

Note : Subjects: healthy volunteers received a cocktail of CYP metabolic probe drugs, including caffeine, dextromethorphan, losartan, and buspirone for assessing the activity of CYP1A2, CYP2D6, CYP2C9, and CYP3A4, resp. Following the baseline evaluation, study participants underwent 4 weeks of green tea catechin intervention at a dose that contains 800 mg epigallocatechin gallate (EGCG) daily. Data incomplete

หน้า 1

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