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THEACEAE Camellia sinensis (L.) Kuntze

Synonym

THEACEAE Thea sinensis L.
THEACEAE Camellia sinensis (L.) Kuntze var. assamica (Mast.) Kitam.

Thai / English name

ชา*

[1-4] of 5 article(s) found

หน้า 1 2

[1] IN VITRO INHIBITION OF HUMAN CYTOCHROME P450-MEDIATED METABOLISM OF MARKER SUBSTRATES BY NATURAL PRODUCTS.
FOSTER BC,VANDENHOEK S,HANA J,ET AL.
PHYTOMEDICINE 2003 Vol.10(),334-42 $11159 [Full]

Part Used : ใบ
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : Aqueous extracts (Darjeeling tea)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Aqueous extracts of bulk spices 25 mg/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Resut: Percent inhibition = 92.1+/-2.47

Part Used : ใบ
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : Aqueous extracts (Earl Grey tea)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Aqueous extracts of bulk spices 25 mg/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Resut: Percent inhibition = 94.2+/-3.79

Part Used : ใบ
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : Aqueous extracts (English breakfast tea)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Aqueous extracts of bulk spices 25 mg/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Resut: Percent inhibition = 95.9+/-3.83

Part Used : ใบ
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : Aqueous extracts (Irish breakfast tea)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Aqueous extracts of bulk spices 25 mg/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Resut: Percent inhibition = 90.5+/-0.36

Part Used : ใบ
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : Aqueous extracts (Orange Pekoe tea)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Aqueous extracts of bulk spices 25 mg/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Resut: Percent inhibition = 97.8+/-1.91

[2] INHIBITORY EFFECTS OF POLYPHENOLS ON HUMAN CYTOCHROME P450 3A4 AND 2C9 ACTIVITY.
KIMURA Y,ITO H,OHNISHI R,ET AL.
FOOD CHEM TOXICOL 2010 Vol.48(),429-35 $27410 [Full]

Part Used : -
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : Kaempferol

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark :

Note : Three coumarins and 12 flavonoids significantly suppressed CYP3A4 or CYP2C9 activities. Lineweaver-Burk plot analysis indicated that apigenin and its dimer amentoflavone and imperatorin displayed a mixed type of inhibition on CYP3A4 or CYP2C9. Among the inhibitors, amentoflavone was the most potent inhibitor of CYP3A4 and CYP2C9 activities with IC50 values of 0.07 and 0.03 micromolar, respectively. The Ki value of amentoflavone was significantly lower than that of the CYP2C9 inhibition positive control sulfaphenazole.

Part Used : -
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : Myricetin

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark :

Note : Three coumarins and 12 flavonoids significantly suppressed CYP3A4 or CYP2C9 activities. Lineweaver-Burk plot analysis indicated that apigenin and its dimer amentoflavone and imperatorin displayed a mixed type of inhibition on CYP3A4 or CYP2C9. Among the inhibitors, amentoflavone was the most potent inhibitor of CYP3A4 and CYP2C9 activities with IC50 values of 0.07 and 0.03 micromolar, respectively. The Ki value of amentoflavone was significantly lower than that of the CYP2C9 inhibition positive control sulfaphenazole.

[3] INTERACTION OF FLURBIPROFEN WITH CRANBERRY JUICE, GRAPE JUICE, TEA, AND FLUCONAZOLE: IN VITRO AND CLINICAL STUDIES.
GREENBLATT DJ,VON MOLTKE LL,PERLOFF ES,ET AL.
CLINICAL PHARMACOLOGY & THERAPEUTICS (NEW YORK, NY, UNITED STATES) 2006 Vol.79(1),125-33 $57343 [Full]

Part Used : -
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 2.5% (v/v)

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: human liver microsomes Results: grape juice and tea inhibited CYP2C9 activity in vitro.

Part Used : -
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : -

Type of experiment : human
Type of animal : -

Type of study : Cross over

N(Total) : 14 (M/F=11/3)
N(Treatment) : 14 (M/F=11/3)

Sex : Both sex
Age : 29+/-8 years (range 19-41 years)

Route : Oral administration
Dose/Conc.(herb) : 8 oz.

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Flurbiprofen
Dose/Conc.(drug) : 100 mg

Result : Negative

Remark : Subject: Healthy volunteers received 100 mg flurbiprofen on 5 occasions in a crossover fashion, with at least 1 week separating the 5 trials. Flurbiprofen was preceded in radom sequence by the following: (1) cranberry juice placebo (8 oz.), (2) cranberry juice (8 oz), (3) brewed tea (8 oz), (4) grape juice (8 oz), and (5) fluconazole, a CYP2C9 inhibitor serving as a positive control, with 8 oz of water. Results: none of the 3 beverages (cranberry juice, grape juice and tea) altered CYP2C9-mediated clearance of flurbiprofen in humans.

[4] EFFECTS OF CONTINUOUS INGESTION OF GREEN TEA OR GRAPE SEED EXTRACTS ON THE PHARMACOKINETICS OF MIDAZOLAM.
NISHIKAWA M,ARIYOSHI N,KOTANI A,ET AL.
DRUG METABOLISM AND PHARMACOKINETICS 2004 Vol.19(4),280-9 271495 [Abstract]

Part Used : ไม่ระบุ
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : 1 weeks
Type of interaction : Pharmacokinetics

Interaction with drug : Midazolam*/Versed/Dormicum
Dose/Conc.(drug) : -

Result : Positive

Remark : Strong inhition of these CYP activities was found by the addn. of green tea ext. or grape seed ext. in vitro.

Note : Data incomplete

หน้า 1 2

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