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Part Used : ใบActivity : CYP1A2 INHIBITIONSolvent/Active Compound :Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : Herbal tea solution (2%, w/v) were prepared stimulating the usual way of brewing tea. Boiled tap water was added to the required weight of tea powder with intermittent stirring for 10 min. The tea brew was than strained through filters to obtain a clear solution, poured in to clean drinking bottles, which were wrapped with light resistant polyethylene sheets, and were given to three groups of rats.Duration : 4 weeksType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark :
Part Used : ไม่ระบุActivity : CYP1A2 INHIBITIONSolvent/Active Compound : green tea exractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : green tea extract 175 mg kg-1Duration : 4 daysType of interaction : PharmacokineticsInteraction with drug : ClozapineDose/Conc.(drug) : 20 mg kg-1Result : PositiveRemark : Green tea extract induced a apprx.2-fold increase in hepatic CYP1A2 levels, while the activity increased slightly (by 10% of control).Note : Data incomplete
Part Used : ไม่ระบุActivity : CYP1A2 INHIBITIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 2.5% decaffeinated black tea ext. (DBTE)Duration : 15 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Treatment with 2.5% decaffeinated black tea ext. (DBTE) or 1% polymeric black tea polyphenol (PBP) mix did not significantly alter the basal activity and level of CYP1A1 and CYP1A2.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYP1A2 INHIBITIONSolvent/Active Compound : polyphenolType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1% polymeric black tea polyphenol (PBP)Duration : 15 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Treatment with 2.5% decaffeinated black tea ext. (DBTE) or 1% polymeric black tea polyphenol (PBP) mix did not significantly alter the basal activity and level of CYP1A1 and CYP1A2.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYP1A2 INHIBITIONSolvent/Active Compound :Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 2.5% decaffeinated black tea ext. (DBTE)Duration : 15 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) :Result : PositiveRemark : Pretreatment with 2.5% decaffeinated black tea ext. (DBTE) or 1% polymeric black tea polyphenol (PBP) mix resulted in a significant decrease in both the activity and the level of B(a)P-induced CYP1A1 and CYP1A2 in liver and lungs.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYP1A2 INHIBITIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1% polymeric black tea polyphenol (PBP)Duration : 15 daysType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) :Result : NegativeRemark : Pretreatment with 2.5% decaffeinated black tea ext. (DBTE) or 1% polymeric black tea polyphenol (PBP) mix resulted in a significant decrease in both the activity and the level of B(a)P-induced CYP1A1 and CYP1A2 in liver and lungs.Note : Data incomplete
Part Used : -Activity : CYP1A2 INHIBITIONSolvent/Active Compound : green tea catechins, epigallocatechin gallate (EGCG)Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 42N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 800 mg epigallocatechin gallate (EGCG) dailyDuration : 4 weeksType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Four weeks of green tea catechin intervention did not alter the phenotypic indexes of CYP1A2, CYP2D6, and CYP2C9, but resulted in a 20% increase (P=0.01) in the area under the plasma buspirone concn.-time profile, suggesting a small reduction in CYP3A4 activity.Note : Subjects: healthy volunteers received a cocktail of CYP metabolic probe drugs, including caffeine, dextromethorphan, losartan, and buspirone for assessing the activity of CYP1A2, CYP2D6, CYP2C9, and CYP3A4, resp. Following the baseline evaluation, study participants underwent 4 weeks of green tea catechin intervention at a dose that contains 800 mg epigallocatechin gallate (EGCG) daily. Data incomplete
Part Used : ใบActivity : CYP1A2 INHIBITIONSolvent/Active Compound : Black tea polyphenolType of experiment : in vivoType of animal : otherType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : 4 weeks before carcinogen administrationType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Administration of polyphenon-B significantly decreased tumor incident, oxidative DNA damage, phase I enzymes (CYP450; CYP1A1, 1A2 and 2B isoforms and cytochrome b5) as well as expression of CYP1A1 and CYP1B1 isoforms.Note : Data incomplete. Type of animal = hamster
Part Used : ใบActivity : CYP1A2 INHIBITIONSolvent/Active Compound : Black tea polyphenolType of experiment : in vivoType of animal : otherType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : 4 weeks after carcinogen administrationType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Administration of BTF-35 significantly decreased tumor incident, oxidative DNA damage, phase I enzymes (CYP450; CYP1A1, 1A2 and 2B isoforms and cytochrome b5) as well as expression of CYP1A1 and CYP1B1 isoforms.Note : Data incomplete. Type of animal = hamster
