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THEACEAE Camellia sinensis (L.) Kuntze

Synonym

THEACEAE Thea sinensis L.
THEACEAE Camellia sinensis (L.) Kuntze var. assamica (Mast.) Kitam.

Thai / English name

ชา*

[1-6] of 12 article(s) found

หน้า 1 2

[1] INTERACTIONS BETWEEN HERBAL AND CONVENTIONAL MEDICINES: THE ROLE OF CYTOCHROME P450 ENZYMES AND P-GLYCOPROTEIN.
WILLIAMSON EM
PHARMACOLOGYONLINE 2006 Vol.2(),200-5 $29296 [Full]

Part Used : ไม่ระบุ
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : Green tea

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Warfarin
Dose/Conc.(drug) : -

Result : Positive

Remark : Catechins inhibit some CYP enzymes and P-gp, but inhibition of CYP enzymes thought to be reason for chemoprotectant effect of tea. Caution with warfarin. Caffeine induces CYP1A2.

Note : Data incomplete, data from review article.

[2] INTERACTIONS BETWEEN HERBAL AND CONVENTIONAL MEDICINES: THE ROLE OF CYTOCHROME P450 ENZYMES AND P-GLYCOPROTEIN.
WILLIAMSON EM
PHARMACOLOGYONLINE 2006 Vol.(2),200-5 $56391 [Full]

Part Used : ไม่ระบุ
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : catechins

Type of experiment : non specified
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : None reported. Catechins inhibit some CYP enzyme and P-gp, but inhibition of CYP enzymes thought to be reason for chemoprotectant effect of tea. Caution with warfarin. Caffeine induces CYP1A2.

Note : Data from review, data incomplete.

[3] INTERACTION OF FLURBIPROFEN WITH CRANBERRY JUICE, GRAPE JUICE, TEA, AND FLUCONAZOLE: IN VITRO AND CLINICAL STUDIES.
GREENBLATT DJ,VON MOLTKE LL,PERLOFF ES,ET AL.
CLINICAL PHARMACOLOGY & THERAPEUTICS (NEW YORK, NY, UNITED STATES) 2006 Vol.79(1),125-33 $57343 [Full]

Part Used : -
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 2.5% (v/v)

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: human liver microsomes Results: grape juice and tea inhibited CYP2C9 activity in vitro.

Part Used : -
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : -

Type of experiment : human
Type of animal : -

Type of study : Cross over

N(Total) : 14 (M/F=11/3)
N(Treatment) : 14 (M/F=11/3)

Sex : Both sex
Age : 29+/-8 years (range 19-41 years)

Route : Oral administration
Dose/Conc.(herb) : 8 oz.

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Flurbiprofen
Dose/Conc.(drug) : 100 mg

Result : Negative

Remark : Subject: Healthy volunteers received 100 mg flurbiprofen on 5 occasions in a crossover fashion, with at least 1 week separating the 5 trials. Flurbiprofen was preceded in radom sequence by the following: (1) cranberry juice placebo (8 oz.), (2) cranberry juice (8 oz), (3) brewed tea (8 oz), (4) grape juice (8 oz), and (5) fluconazole, a CYP2C9 inhibitor serving as a positive control, with 8 oz of water. Results: none of the 3 beverages (cranberry juice, grape juice and tea) altered CYP2C9-mediated clearance of flurbiprofen in humans.

[4] EFFECT OF POLYMERIC BLACK TEA POLYPHENOLS ON BENZO(A)PYRENE [B(A)P]-INDUCED CYTOCHROME P4501A1 AND 1A2 IN MICE.
KRISHNAN R,RAGHUNATHAN R,MARU GB
XENOBIOTICA 2005 Vol.35(7),671-82 300387 [Abstract]

Part Used : ไม่ระบุ
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 2.5% decaffeinated black tea ext. (DBTE)

Duration : 15 days
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Treatment with 2.5% decaffeinated black tea ext. (DBTE) or 1% polymeric black tea polyphenol (PBP) mix did not significantly alter the basal activity and level of CYP1A1 and CYP1A2.

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : polyphenol

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 1% polymeric black tea polyphenol (PBP)

Duration : 15 days
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Treatment with 2.5% decaffeinated black tea ext. (DBTE) or 1% polymeric black tea polyphenol (PBP) mix did not significantly alter the basal activity and level of CYP1A1 and CYP1A2.

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound :

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 2.5% decaffeinated black tea ext. (DBTE)

Duration : 15 days
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) :

Result : Positive

Remark : Pretreatment with 2.5% decaffeinated black tea ext. (DBTE) or 1% polymeric black tea polyphenol (PBP) mix resulted in a significant decrease in both the activity and the level of B(a)P-induced CYP1A1 and CYP1A2 in liver and lungs.

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 1% polymeric black tea polyphenol (PBP)

Duration : 15 days
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) :

Result : Negative

Remark : Pretreatment with 2.5% decaffeinated black tea ext. (DBTE) or 1% polymeric black tea polyphenol (PBP) mix resulted in a significant decrease in both the activity and the level of B(a)P-induced CYP1A1 and CYP1A2 in liver and lungs.

Note : Data incomplete

[5] PROTECTIVE EFFECTS OF TEA MELANIN AGAINST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED TOXICITY: ANTIOXIDANT ACTIVITY AND ARYL HYDROCARBON RECEPTOR SUPPRESSIVE EFFECT.
HUNG Y-C,HUANG GS,SAVA VM,ET AL.
BIOL PHARM BULL 2006 Vol.29(11),2284-91 340171 [Abstract]

Part Used : -
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : tea melanin

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 40 mg/kg

Duration : 14 days
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Both reduced tea melanin and non-reduced tea melanin suppressed the expression of CYP1A1 gene and prevented the activation of cytochrome P 450 isoenzyme in the livers of animals exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Note : Data incomplete

[6] INHIBITORY EFFECT OF TEA BEVERAGES ON HUMAN CYTOCHROME P 450 3A (CYP 3A) ACTIVITY.
OGIKUBO T,HIDAKA M,OKUMURA M,ET AL.
IRYO YAKUGAKU 2006 Vol.32(5),392-9 342144 [Abstract]

Part Used : -
Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: human liver microsomes Results: Tea beverages tested significantly inhibited the midazolam 1'-hydroxylation activity of CYP 3A in a concn.-dependent manner.

Note : Data incomplete

หน้า 1 2

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