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THEACEAE Camellia sinensis (L.) Kuntze

Synonym

THEACEAE Thea sinensis L.
THEACEAE Camellia sinensis (L.) Kuntze var. assamica (Mast.) Kitam.

Thai / English name

ชา*

[1-1] of 2 article(s) found

หน้า 1 2 3

[1] EPIGALLOCATECHIN GALLATE, ELLAGIC ACID, AND ROSMARINIC ACID PERTURB DNTP POOLS AND INHIBIT DE NOVO DNA SYNTHESIS AND PROLIFERATION OF HUMAN HL-60 PROMYELOCYTIC LEUKEMIA CELLS: SYNERGISM WITH ARABINOFURANOSYLCYTOSINE.
PHILIPP SAIKO, MARIE-THERESE STEINMANN, HEIKE SCHUSTER,ET AL.
PHYTOMEDICINE 2015 Vol.22(),213-22 $54161 [Full]

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT

Solvent/Active Compound : EGCG

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 15 micromolar/nM

Duration : 24 h.
Type of interaction : Pharmacodynamics

Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 5 micromolar/nM

Result : Positive

Remark : - Cell number (% of control) 81.3 - Combination index 1.328 - Six out of nine combinations applied yielded additive effects.

Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT

Solvent/Active Compound : EGCG

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 15 micromolar/nM

Duration : 24 h.
Type of interaction : Pharmacodynamics

Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 10 micromolar/nM

Result : Positive

Remark : - Cell number (% of control) 73.6 - Combination index 1.319 - Six out of nine combinations

Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT

Solvent/Active Compound : EGCG

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 15 micromolar/nM

Duration : 24 h.
Type of interaction : Pharmacodynamics

Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 20 micromolar/nM

Result : Positive

Remark : - Cell number (% of control) 58.7 - Combination index 1.136 - Six out of nine combinations applied yielded additive effects.

Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT

Solvent/Active Compound : EGCG

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 20 micromolar/nM

Duration : 24 h.
Type of interaction : Pharmacodynamics

Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 5 micromolar/nM

Result : Positive

Remark : - Cell number (% of control) 55.9 - Combination index 1.030 (Additive combination effect) - Six out of nine combinations applied yielded additive effects.

Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT

Solvent/Active Compound : EGCG

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 20 micromolar/nM

Duration : 24 h.
Type of interaction : Pharmacodynamics

Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 10 micromolar/nM

Result : Positive

Remark : - Cell number (% of control) 53.0 - Combination index 1.078 (Additive combination effect) - Six out of nine combinations applied yielded additive effects.

Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT

Solvent/Active Compound : EGCG

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 20 micromolar/nM

Duration : 24 h.
Type of interaction : Pharmacodynamics

Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 20 micromolar/nM

Result : Positive

Remark : - Cell number (% of control) 39.7 - Combination index 1.004 (Additive combination effect) - Six out of nine combinations applied yielded additive effects.

Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT

Solvent/Active Compound : EGCG

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 25 micromolar/nM

Duration : 24 h.
Type of interaction : Pharmacodynamics

Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 5 micromolar/nM

Result : Positive

Remark : - Cell number (% of control) 15.8 - Combination index 0.941 (Additive combination effect) - Six out of nine combinations applied yielded additive effects.

Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT

Solvent/Active Compound : EGCG

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 25 micromolar/nM

Duration : 24 h.
Type of interaction : Pharmacodynamics

Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 10 micromolar/nM

Result : Positive

Remark : - Cell number (% of control) 17.8 - Combination index 0.941 (Additive combination effect) - Six out of nine combinations applied yielded additive effects.

Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT

Solvent/Active Compound : EGCG

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 25 micromolar/nM

Duration : 24 h.
Type of interaction : Pharmacodynamics

Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 20 micromolar/nM

Result : Positive

Remark : - Cell number (% of control) 14.4 - Combination index 0.916 (Additive combination effect) - Six out of nine combinations applied yielded additive effects.

Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

Part Used : ไม่ระบุ
Activity : CELL GROWTH INHIBITION EFFECT

Solvent/Active Compound : EA

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 10 micromolar/nM

Duration : 24 h.
Type of interaction : Pharmacodynamics

Interaction with drug : Arabinofuranosylcytosine*/Arabinosylcytosine/Cytarabine/Ara-C/Cytosine arabinosine
Dose/Conc.(drug) : 5 micromolar/nM

Result : Positive

Remark : - Cell number (% of control) 87.3 - Combination index 1.285 - Four out of nine EA combinations applied showed synergism.

Note : - Test in HL-60 promyelocytic leukemia cells. - Cells were sequentially incubated with EGCG, EA and RA for 24 h and AraC for 48 h. Abbreviations - Epigallocatechin gallate : EGCG - Ellagic acid : EA - Rosmarinic acid : RA - Arabinofuranosylcytosine : AraC

หน้า 1 2 3

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