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| Thai / English name |
Part Used : ใบActivity : CYP3A4 INDUCTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : FemaleAge : 42 yrsRoute : Oral administrationDose/Conc.(herb) : 1 g/ die of catechinsDuration : 10 daysType of interaction : PharmacokineticsInteraction with drug : IrbesartanDose/Conc.(drug) : 150 mg/dayResult : PositiveRemark : The patient, carrying genetic variant of hepatic metabolism making her particularly susceptible to oxidative stress, developed an abnormal response to a mild toxic insult, afforded by a combination of agents (oral contraceptives + irbesartan + green tea) that normally would not be able to cause damage. Her particular hepatic metabolism might have further increased the drugs' concentration, favoring the haptenization of liver proteins, eventually leading to the development of an autoimmune hepatitis.
Part Used : ใบActivity : CYP3A4 INDUCTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : FemaleAge : 42 yrsRoute : Oral administrationDose/Conc.(herb) : 1 g/ die of catechinsDuration : 10 daysType of interaction : PharmacokineticsInteraction with drug : GestodeneDose/Conc.(drug) : -Result : PositiveRemark : The patient, carrying genetic variant of hepatic metabolism making her particularly susceptible to oxidative stress, developed an abnormal response to a mild toxic insult, afforded by a combination of agents (oral contraceptives + irbesartan + green tea) that normally would not be able to cause damage. Her particular hepatic metabolism might have further increased the drugs' concentration, favoring the haptenization of liver proteins, eventually leading to the development of an autoimmune hepatitis. *Interaction with a combination of gestodene and 17alpha-ethinylestradiol as oral contraceptive
Part Used : ใบActivity : CYP3A4 INDUCTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : FemaleAge : 42 yrsRoute : Oral administrationDose/Conc.(herb) : 1 g/ die of catechinsDuration : 10 daysType of interaction : PharmacokineticsInteraction with drug : Estradiol*/17 alpha-ethinylestradiolDose/Conc.(drug) : -Result : PositiveRemark : The patient, carrying genetic variant of hepatic metabolism making her particularly susceptible to oxidative stress, developed an abnormal response to a mild toxic insult, afforded by a combination of agents (oral contraceptives + irbesartan + green tea) that normally would not be able to cause damage. Her particular hepatic metabolism might have further increased the drugs' concentration, favoring the haptenization of liver proteins, eventually leading to the development of an autoimmune hepatitis. *Interaction with a combination of gestodene and 17alpha-ethinylestradiol as oral contraceptive
Part Used : ไม่ระบุActivity : CYP3A4 INDUCTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : 1 weeksType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : Although single treatments with green tea exts. or grape seed ext. had negligible effects, 1 wk of treatment with them resulted in a significant increase in the ke of i.v. administered midazolam (MDZ), indicating the induction of CYP3A in the liver.Note : Data incomplete
