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THEACEAE Camellia sinensis (L.) Kuntze

Synonym

THEACEAE Thea sinensis L.
THEACEAE Camellia sinensis (L.) Kuntze var. assamica (Mast.) Kitam.

Thai / English name

ชา*

[1-4] of 4 article(s) found

หน้า 1

[1] INTERACTIONS BETWEEN HERBAL AND CONVENTIONAL MEDICINES: THE ROLE OF CYTOCHROME P450 ENZYMES AND P-GLYCOPROTEIN.
WILLIAMSON EM
PHARMACOLOGYONLINE 2006 Vol.2(),200-5 $29296 [Full]

Part Used : ไม่ระบุ
Activity : CYP1A2 INDUCTION

Solvent/Active Compound : Green tea

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Warfarin
Dose/Conc.(drug) : -

Result : Positive

Remark : Catechins inhibit some CYP enzymes and P-gp, but inhibition of CYP enzymes thought to be reason for chemoprotectant effect of tea. Caution with warfarin. Caffeine induces CYP1A2.

Note : Data incomplete, data from review article.

[2] INTERACTIONS BETWEEN HERBAL AND CONVENTIONAL MEDICINES: THE ROLE OF CYTOCHROME P450 ENZYMES AND P-GLYCOPROTEIN.
WILLIAMSON EM
PHARMACOLOGYONLINE 2006 Vol.(2),200-5 $56391 [Full]

Part Used : ไม่ระบุ
Activity : CYP1A2 INDUCTION

Solvent/Active Compound : caffeine

Type of experiment : non specified
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : None reported. Catechins inhibit some CYP enzyme and P-gp, but inhibition of CYP enzymes thought to be reason for chemoprotectant effect of tea. Caution with warfarin. Caffeine induces CYP1A2.

Note : Data from review, data incomplete.

[3] SHORT-TERM BLACK TEA INTAKE MODULATES THE EXCRETION OF URINARY MUTAGENS IN RATS TREATED WITH 2-AMINO-3-METHYLIMIDAZO-[4,5-F]QUINOLINE (IQ): ROLE OF CYP1A2 UPREGULATION.
YOXALL VR,PARKER DA,KENTISH PA,ET AL.
ARCH TOXICOL 2004 Vol.78(8),477-82 274235 [Abstract]

Part Used : ไม่ระบุ
Activity : CYP1A2 INDUCTION

Solvent/Active Compound : -

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : black tea (2.5% w/v)

Duration : 1 day
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Black tea treatment induced hepatic CYP1A2 activity and expression.

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : CYP1A2 INDUCTION

Solvent/Active Compound : -

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : black tea (2.5% w/v)

Duration : 1 month
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Black tea treatment induced hepatic CYP1A2 activity and expression.

Note : Data incomplete

[4] EFFECTS OF CHINESE, JAPANESE AND WESTERN TEA ON HEPATIC P450 ENZYME ACTIVITIES IN RATS.
NIWATTISAIWONG N,LUO X-X,COVILLE PF,ET AL.
DRUG METABOL DRUG INTERACT 2004 Vol.20(1-2),43-56 275073 [Abstract]

Part Used : ใบ
Activity : CYP1A2 INDUCTION

Solvent/Active Compound :

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : -

Duration : 4 weeks
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : No change was observed in the activity of CYP1A2 in any of tested animals.

Note : - Female Wistar rats were divided into five group (n=4 each); each had free access to tea solutions while the control group was supplied with water. Data complete

หน้า 1

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