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Part Used : -Activity : ANTITUMOR ACTIVITYSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : Tamoxifen*/TAMDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: mouse xenograft model Results: Mice treated with both green tea and tamoxifen had the smallest MCF-7 xenograft tumor size, and the highest levels of apoptosis in tumor tissue, as compared with either agent administered alone. moreover, the suppression of angiogenesis in vivo correlated with larger areas of necrosis and lower tumor blood vessel density in treated xenografts. The combination of green tea and tamoxifen significantly reduced the levels of estrogen receptor (ER)-alpha, in comparison to either agent alone.Note : Data incomplete
Part Used : -Activity : ANTITUMOR ACTIVITYSolvent/Active Compound : green tea polyphenolsType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 0.1% in drinking waterDuration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : CelecoxibDose/Conc.(drug) : 5 mg/kg, i.p., daily, 5 days per weeksResult : PositiveRemark : Type of animal: nude mice Results: Combination treatment with green tea polyphenols and celecoxib resulted in enhanced (a) tumor growth inhibition, (b) lowering of prostate-specific antigen levels, (c) lowering of insulin-like growth factor-l levels, and (d) circulating levels of serum insulin-like growth factor binding protein-3 compared with results of single-agent treatment.Note : Data incomplete
