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Part Used : ไม่ระบุActivity : APOPTOSIS INHIBITIONSolvent/Active Compound : Green tea extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 10 microgram/mL, Green tea extractDuration : -Type of interaction : PharmacodynamicsInteraction with drug : Imipenem*/Imipemide/Imipenemum/N-formimidoylthienamycin/TienamycinDose/Conc.(drug) : 5 micromolarResult : PositiveRemark : Type of experiment: rat thymocyte. Green tea ext. inhibited 5 micromolar etoposide-induced DNA fragmentation and activation of caspase-3-like proteases in thymocytes isolated from Wistar rats (7-8 wk old, male).Note : These results indicate that the ingestion of tea reduces the risk of the side effect of etoposide, which have been clin. administered in chemotherapy as an anticancer drug. Data incomplete
Part Used : ไม่ระบุActivity : APOPTOSIS INHIBITIONSolvent/Active Compound : hexane fraction of green tea ext.Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 microgram/mLDuration : -Type of interaction : PharmacodynamicsInteraction with drug : Imipenem*/Imipemide/Imipenemum/N-formimidoylthienamycin/TienamycinDose/Conc.(drug) : 5 micromolarResult : PositiveRemark : Type of experiment: rat thymocyte. When the green tea ext. was fractionated into four fractions by successive extn. with hexane, chloroform, Et acetate, and n-butanol; the Et acetate and n-butanol fractions (5 microgram/mL) showed a stronger inhibitory effect compared with the other fractions.Note : These results indicate that the ingestion of tea reduces the risk of the side effect of etoposide, which have been clin. administered in chemotherapy as an anticancer drug. Data incomplete
Part Used : ไม่ระบุActivity : APOPTOSIS INHIBITIONSolvent/Active Compound : chloroform fraction of green tea ext.Type of experiment : in vitroType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 microgram/mLDuration : -Type of interaction : PharmacodynamicsInteraction with drug : Imipenem*/Imipemide/Imipenemum/N-formimidoylthienamycin/TienamycinDose/Conc.(drug) : 5 micromolarResult : PositiveRemark : Type of experiment: rat thymocyte. When the green tea ext. was fractionated into four fractions by successive extn. with hexane, chloroform, Et acetate, and n-butanol; the Et acetate and n-butanol fractions (5 microgram/mL) showed a stronger inhibitory effect compared with the other fractions.Note : These results indicate that the ingestion of tea reduces the risk of the side effect of etoposide, which have been clin. administered in chemotherapy as an anticancer drug. Data incomplete
Part Used : ไม่ระบุActivity : APOPTOSIS INHIBITIONSolvent/Active Compound : Et acetate fraction of green tea ext.Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 microgram/mLDuration : -Type of interaction : PharmacodynamicsInteraction with drug : Imipenem*/Imipemide/Imipenemum/N-formimidoylthienamycin/TienamycinDose/Conc.(drug) : 5 micromolarResult : PositiveRemark : Type of experiment: rat thymocyte. When the green tea ext. was fractionated into four fractions by successive extn. with hexane, chloroform, Et acetate, and n-butanol; the Et acetate and n-butanol fractions (5 microgram/mL) showed a stronger inhibitory effect compared with the other fractions.Note : These results indicate that the ingestion of tea reduces the risk of the side effect of etoposide, which have been clin. administered in chemotherapy as an anticancer drug. Data incomplete
Part Used : ไม่ระบุActivity : APOPTOSIS INHIBITIONSolvent/Active Compound : n-butanol fraction of green tea ext.Type of experiment : in vitroType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 microgram/mL, Green tea extractDuration : -Type of interaction : PharmacodynamicsInteraction with drug : Imipenem*/Imipemide/Imipenemum/N-formimidoylthienamycin/TienamycinDose/Conc.(drug) : 5 micromolarResult : PositiveRemark : Type of experiment: rat thymocyte. When the green tea ext. was fractionated into four fractions by successive extn. with hexane, chloroform, Et acetate, and n-butanol; the Et acetate and n-butanol fractions (5 microgram/mL) showed a stronger inhibitory effect compared with the other fractions.Note : These results indicate that the ingestion of tea reduces the risk of the side effect of etoposide, which have been clin. administered in chemotherapy as an anticancer drug. Data incomplete
Part Used : ไม่ระบุActivity : APOPTOSIS INHIBITIONSolvent/Active Compound : green tea ext.Type of experiment : ex vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 5 mg/kg body wt., green tea ext. in 0.9% NaClDuration : 12 daysType of interaction : PharmacodynamicsInteraction with drug : Imipenem*/Imipemide/Imipenemum/N-formimidoylthienamycin/TienamycinDose/Conc.(drug) : 5 micromolarResult : PositiveRemark : Ex vivo expts. demonstrated that a single oral dose of green tea ext. (5 mg/kg body wt.) in 0.9% NaCl or the ad libitum ingestion of the green tea ext. (2 mg/mL in drinking water) for 12 days inhibited etoposide-induced apoptosis in the thymocytes.Note : These results indicate that the ingestion of tea reduces the risk of the side effect of etoposide, which have been clin. administered in chemotherapy as an anticancer drug. Data incomplete
Part Used : ไม่ระบุActivity : APOPTOSIS INHIBITIONSolvent/Active Compound : green tea ext.Type of experiment : ex vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 2 mg/mL, green tea ext. in drinking waterDuration : 12 daysType of interaction : PharmacodynamicsInteraction with drug : Imipenem*/Imipemide/Imipenemum/N-formimidoylthienamycin/TienamycinDose/Conc.(drug) : 5 micromolarResult : PositiveRemark : Ex vivo expts. demonstrated that a single oral dose of green tea ext. (5 mg/kg body wt.) in 0.9% NaCl or the ad libitum ingestion of the green tea ext. (2 mg/mL in drinking water) for 12 days inhibited etoposide-induced apoptosis in the thymocytes.Note : These results indicate that the ingestion of tea reduces the risk of the side effect of etoposide, which have been clin. administered in chemotherapy as an anticancer drug. Data incomplete
Part Used : ไม่ระบุActivity : APOPTOSIS INHIBITIONSolvent/Active Compound : black tea extractType of experiment : in vitroType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 microgram/mLDuration : -Type of interaction : PharmacodynamicsInteraction with drug : Imipenem*/Imipemide/Imipenemum/N-formimidoylthienamycin/TienamycinDose/Conc.(drug) : 5 micromolarResult : PositiveRemark : Type of experiment: rat thymocyte. Black tea ext. and its n-butanol fraction also inhibited etoposide-induced apoptosis.Note : These results indicate that the ingestion of tea reduces the risk of the side effect of etoposide, which have been clin. administered in chemotherapy as an anticancer drug. Data incomplete
Part Used : ไม่ระบุActivity : APOPTOSIS INHIBITIONSolvent/Active Compound : n-butanol fraction of black teaType of experiment : in vitroType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 microgram/mLDuration : -Type of interaction : PharmacodynamicsInteraction with drug : Imipenem*/Imipemide/Imipenemum/N-formimidoylthienamycin/TienamycinDose/Conc.(drug) : 5 micromolarResult : PositiveRemark : Type of experiment: rat thymocyte. Black tea ext. and its n-butanol fraction also inhibited etoposide-induced apoptosis.Note : These results indicate that the ingestion of tea reduces the risk of the side effect of etoposide, which have been clin. administered in chemotherapy as an anticancer drug. Data incomplete
