Part Used : ไม่ระบุ
Activity : COAGULANT ACTIVITY
Solvent/Active Compound : vitamin K
Type of experiment : human
Type of animal : -
Type of study : Case report
N(Total) : 1 (M/F=1/-)
N(Treatment) : 1 (M/F=1/-)
Sex : Male
Age : 44 years old
Route : Oral administration
Dose/Conc.(herb) : one-half to one gallon of green tea per day
Duration : one week
Type of interaction : Pharmacodynamics
Interaction with drug : Warfarin
Dose/Conc.(drug) : -
Remark : -The patient was receiving warfarin for thromboembolic prophylaxis. The patient had an international normalized ratio (INR) of 3.79 on entering our clinic. Twenty-two days later his INR was 1.37. One month later the patient's INR was 1.14. It was subsequently discovered that the patient began drinking one-half to one gallon of green tea per day about one week prior to the INR of 1.37. On discontinuation of the green tea, the patient's INR increase to 2.55.
- Green tea can be a significant source of vitamin K and thus antagonize the effect of warfarin.