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Thai / English name |
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : green tea extract (GTE)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 400 mg/kgDuration : 30 min.*Type of interaction : PharmacokineticsInteraction with drug : Nadolol*/CorgardDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : - Pretreatment with GTE resulted in marked reductions in the maximum concentration (Cmax) and area under the time-plasma concentration curve (AUC) of nadolol by 85% and 74%, respectively, as compared with control. In addition, EGCG alone significantly reduced Cmax and AUC of nadolol. Amounts of nadolol excreted into the urine were decreased by pretreatments with GTE and EGCG, while the terminal half-life on nadolol was not different among groups.Note : Duration: *Rats received green tea extract (GTE) and (-)-epigallocatechin-3-gallate (EGCG) or saline (control) by oral gavage, 30 min before a single intragastric administratiion of nadolol. - These results suggest that the coadministration with green tea catechins, particularly EGCG, causes a significant alteration in the pharmacokinetics of nadolol.
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : green tea extract (GTE)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 400 mg/kgDuration : 30 min.*Type of interaction : PharmacokineticsInteraction with drug : Nadolol*/CorgardDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : - Pretreatment with GTE resulted in marked reductions in the maximum concentration (Cmax) and area under the time-plasma concentration curve (AUC) of nadolol by 85% and 74%, respectively, as compared with control. In addition, EGCG alone significantly reduced Cmax and AUC of nadolol. Amounts of nadolol excreted into the urine were decreased by pretreatments with GTE and EGCG, while the terminal half-life on nadolol was not different among groups.Note : Duration: *Rats received green tea extract (GTE) and (-)-epigallocatechin-3-gallate (EGCG) or saline (control) by oral gavage, 30 min before a single intragastric administratiion of nadolol. - These results suggest that the coadministration with green tea catechins, particularly EGCG, causes a significant alteration in the pharmacokinetics of nadolol.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : (-)-epigallocatechin-3-gallate (EGCG)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 150 mg/kgDuration : 30 min.*Type of interaction : PharmacokineticsInteraction with drug : Nadolol*/CorgardDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : - Pretreatment with GTE resulted in marked reductions in the maximum concentration (Cmax) and area under the time-plasma concentration curve (AUC) of nadolol by 85% and 74%, respectively, as compared with control. In addition, EGCG alone significantly reduced Cmax and AUC of nadolol. Amounts of nadolol excreted into the urine were decreased by pretreatments with GTE and EGCG, while the terminal half-life on nadolol was not different among groups.Note : Duration: *Rats received green tea extract (GTE) and (-)-epigallocatechin-3-gallate (EGCG) or saline (control) by oral gavage, 30 min before a single intragastric administratiion of nadolol. - These results suggest that the coadministration with green tea catechins, particularly EGCG, causes a significant alteration in the pharmacokinetics of nadolol.
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : (-)-epigallocatechin-3-gallate (EGCG)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 150 mg/kgDuration : 30 min.*Type of interaction : PharmacokineticsInteraction with drug : Nadolol*/CorgardDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : - Pretreatment with GTE resulted in marked reductions in the maximum concentration (Cmax) and area under the time-plasma concentration curve (AUC) of nadolol by 85% and 74%, respectively, as compared with control. In addition, EGCG alone significantly reduced Cmax and AUC of nadolol. Amounts of nadolol excreted into the urine were decreased by pretreatments with GTE and EGCG, while the terminal half-life on nadolol was not different among groups.Note : Duration: *Rats received green tea extract (GTE) and (-)-epigallocatechin-3-gallate (EGCG) or saline (control) by oral gavage, 30 min before a single intragastric administratiion of nadolol. - These results suggest that the coadministration with green tea catechins, particularly EGCG, causes a significant alteration in the pharmacokinetics of nadolol.