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Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : EGCG (-)-epigallocatechin-3-gallateType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : ErlotinibDose/Conc.(drug) : -Result : PositiveRemark : In vitro studies with 5 head and neck cancer cell lines revealed that synergistic cell growth inhibition by the combination of EGCG and erlotinib was associated with significantly greater inhibition of pEGFR and pAKT, increased activation of caspases 9, 3 and PARP compared to the inhibition induced by EGCG or erlotinib alone.Note : Data incomplete.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : EGCG (-)-epigallocatechin-3-gallateType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : The combination of EGCG and erlotinib was orally gavaged at the same doses for 7 days, followed by s.c. injection with Tu212 cells. Animals were continuously administered the agents 5 days weekly for 7 wk.Type of interaction : PharmacodynamicsInteraction with drug : ErlotinibDose/Conc.(drug) : -Result : PositiveRemark : The combined treatment resulted in significantly greater inhibition of tumor growth and delayed tumor progression as a result of increased apoptosis, decreased cell proliferation and reduced pEGFR and pAKT compared to the single agent treatment groups.Note : Data incomplete.
