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Part Used : ไม่ระบุActivity : CYP2C19 INDUCTIONSolvent/Active Compound : polyphenols (TP)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : OtherDose/Conc.(herb) : TP400 mg.kg-1Duration : 14 daysType of interaction : PharmacokineticsInteraction with drug : LansoprazoleDose/Conc.(drug) : 8 mg.kg-1Result : PositiveRemark : Route: Intragastrically - The pharmacokinetic parameters showed that TP decreased the AUC (0-4), Cmax and t1/2z remarkably, increased the AUC (0-4) ratios of 5-hydroxylansoprazole to lansoprazole sulfone significantly (P<0.05), while showed no significant influence on the pharmacokinetics of lansoprazole sulfone (P>0.05). TP could decrease the bioavailability of lansoprazole in rats significantly, which was probably related to the induction of CYP2C19 by TP.Note : Data incomplete
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : polyphenols (TP)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : OtherDose/Conc.(herb) : TP400 mg.kg-1Duration : 14 daysType of interaction : PharmacokineticsInteraction with drug : LansoprazoleDose/Conc.(drug) : 8 mg.kg-1Result : PositiveRemark : Route: Intragastrically - The pharmacokinetic parameters showed that TP decreased the AUC (0-4), Cmax and t1/2z remarkably, increased the AUC (0-4) ratios of 5-hydroxylansoprazole to lansoprazole sulfone significantly (P<0.05), while showed no significant influence on the pharmacokinetics of lansoprazole sulfone (P>0.05). TP could decrease the bioavailability of lansoprazole in rats significantly, which was probably related to the induction of CYP2C19 by TP.Note : Data incomplete