ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : -

Activity : DRUG INTERACTION

Solvent/Active Compound : green tea catechins (GTC)

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : 1 GTC

Duration : 42 weeks

Type of interaction : P.Kinetics & P.Dynamics

Interaction with drug : Sodium nitrite

Dose/Conc.(drug) : 0.2%

Result : Positive

Remark : Combined treatment with green tea catechins and sodium nitrite selectively promotes rat forestomach carcinogenesis after initiation with N-methyl-N'-nitro-nitrosoguanidine.

Note : Type of experiment: male rats were given 0.01% N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in their drinking water and 5% NaCl in the diet for 10 wk for glandular stomach initiation and a single intragastric administration of 100 mg/kg/bodyweight of MNNG at week 9 for forestomach initiation. From week 11, they received either drinking water contg. 0.2% sodium nitrite (NaNO2) and a diet supplemented with 1% GTC in combination, each individual chem. alone or a basal diet until the end of week 42. Data incomplete

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