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THEACEAE Camellia sinensis (L.) Kuntze

Synonym

THEACEAE Thea sinensis L.
THEACEAE Camellia sinensis (L.) Kuntze var. assamica (Mast.) Kitam.

Thai / English name

ชา*

[1-1] of 1 article(s) found

หน้า 1

[1] THE COMBINATION OF GREEN TEA AND TAMOXIFEN IS EFFECTIVE AGAINST BREAST CANCER.
SARTIPPOUR MR,PIETRAS R,MARQUEZ-GARBAN DC,ET AL.
CARCINOGENESIS 2006 Vol.27(12),2424-33 336618 [Abstract]

Part Used : -
Activity : ANTIPROLIFERATION ACTIVITY

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : P.Kinetics & P.Dynamics

Interaction with drug : Tamoxifen*/TAM
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: human breast cancer cell lines MCF-7, ZR75, T47D Results: Green tea increased the inhibitory effect of tamoxifen on the proliferation of the ER (estrogen receptor)-pos. MCF-7, 2R75, T47D human breast cancer cells in vitro. This combination regimen was also more potent than either agent alone at increasing cell apoptosis.

Note : Data incomplete

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : P.Kinetics & P.Dynamics

Interaction with drug : Tamoxifen*/TAM
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: human breast cancer cell lines MCF-7, ZR75, T47D Results: Green tea increased the inhibitory effect of tamoxifen on the proliferation of the ER (estrogen receptor)-pos. MCF-7, 2R75, T47D human breast cancer cells in vitro. This combination regimen was also more potent than either agent alone at increasing cell apoptosis.

Note : Data incomplete

Part Used : -
Activity : APOPTOSIS INDUCTION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : P.Kinetics & P.Dynamics

Interaction with drug : Tamoxifen*/TAM
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: human breast cancer cell lines MCF-7, ZR75, T47D Results: Green tea increased the inhibitory effect of tamoxifen on the proliferation of the ER (estrogen receptor)-pos. MCF-7, 2R75, T47D human breast cancer cells in vitro. This combination regimen was also more potent than either agent alone at increasing cell apoptosis.

Note : Data incomplete

Part Used : -
Activity : CELL PROLIFERATION INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : P.Kinetics & P.Dynamics

Interaction with drug : Tamoxifen*/TAM
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: human breast cancer cell lines MCF-7, ZR75, T47D Results: Green tea increased the inhibitory effect of tamoxifen on the proliferation of the ER (estrogen receptor)-pos. MCF-7, 2R75, T47D human breast cancer cells in vitro. This combination regimen was also more potent than either agent alone at increasing cell apoptosis.

Note : Data incomplete

Part Used : -
Activity : ESTROGEN BINDING INHIBITION

Solvent/Active Compound : -

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : P.Kinetics & P.Dynamics

Interaction with drug : Tamoxifen*/TAM
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: mouse xenograft model Results: Mice treated with both green tea and tamoxifen had the smallest MCF-7 xenograft tumor size, and the highest levels of apoptosis in tumor tissue, as compared with either agent administered alone. moreover, the suppression of angiogenesis in vivo correlated with larger areas of necrosis and lower tumor blood vessel density in treated xenografts. The combination of green tea and tamoxifen significantly reduced the levels of estrogen receptor (ER)-alpha, in comparison to either agent alone.

Note : Data incomplete

Part Used : -
Activity : TUMOR NEOVASCULAR DAMAGE INDUCTION

Solvent/Active Compound : -

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : P.Kinetics & P.Dynamics

Interaction with drug : Tamoxifen*/TAM
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: mouse xenograft model Results: Mice treated with both green tea and tamoxifen had the smallest MCF-7 xenograft tumor size, and the highest levels of apoptosis in tumor tissue, as compared with either agent administered alone. moreover, the suppression of angiogenesis in vivo correlated with larger areas of necrosis and lower tumor blood vessel density in treated xenografts. The combination of green tea and tamoxifen significantly reduced the levels of estrogen receptor (ER)-alpha, in comparison to either agent alone.

Note : Data incomplete

Part Used : -
Activity : APOPTOSIS INDUCTION

Solvent/Active Compound : -

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : P.Kinetics & P.Dynamics

Interaction with drug : Tamoxifen*/TAM
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: mouse xenograft model Results: Mice treated with both green tea and tamoxifen had the smallest MCF-7 xenograft tumor size, and the highest levels of apoptosis in tumor tissue, as compared with either agent administered alone. moreover, the suppression of angiogenesis in vivo correlated with larger areas of necrosis and lower tumor blood vessel density in treated xenografts. The combination of green tea and tamoxifen significantly reduced the levels of estrogen receptor (ER)-alpha, in comparison to either agent alone.

Note : Data incomplete

Part Used : -
Activity : ANGIOGENESIS INHIBITION

Solvent/Active Compound : -

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : P.Kinetics & P.Dynamics

Interaction with drug : Tamoxifen*/TAM
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: mouse xenograft model Results: Mice treated with both green tea and tamoxifen had the smallest MCF-7 xenograft tumor size, and the highest levels of apoptosis in tumor tissue, as compared with either agent administered alone. moreover, the suppression of angiogenesis in vivo correlated with larger areas of necrosis and lower tumor blood vessel density in treated xenografts. The combination of green tea and tamoxifen significantly reduced the levels of estrogen receptor (ER)-alpha, in comparison to either agent alone.

Note : Data incomplete

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : -

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : P.Kinetics & P.Dynamics

Interaction with drug : Tamoxifen*/TAM
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: mouse xenograft model Results: Mice treated with both green tea and tamoxifen had the smallest MCF-7 xenograft tumor size, and the highest levels of apoptosis in tumor tissue, as compared with either agent administered alone. moreover, the suppression of angiogenesis in vivo correlated with larger areas of necrosis and lower tumor blood vessel density in treated xenografts. The combination of green tea and tamoxifen significantly reduced the levels of estrogen receptor (ER)-alpha, in comparison to either agent alone.

Note : Data incomplete

Part Used : -
Activity : ANTITUMOR ACTIVITY

Solvent/Active Compound : -

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : P.Kinetics & P.Dynamics

Interaction with drug : Tamoxifen*/TAM
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: mouse xenograft model Results: Mice treated with both green tea and tamoxifen had the smallest MCF-7 xenograft tumor size, and the highest levels of apoptosis in tumor tissue, as compared with either agent administered alone. moreover, the suppression of angiogenesis in vivo correlated with larger areas of necrosis and lower tumor blood vessel density in treated xenografts. The combination of green tea and tamoxifen significantly reduced the levels of estrogen receptor (ER)-alpha, in comparison to either agent alone.

Note : Data incomplete

หน้า 1

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