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Part Used : ใบActivity : UDP-GLUCURONYL TRANSFERASE INHIBITIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : FemaleAge : 42 yrsRoute : Oral administrationDose/Conc.(herb) : 1 g/ die of catechinsDuration : 10 daysType of interaction : PharmacokineticsInteraction with drug : Estradiol*/17 alpha-ethinylestradiolDose/Conc.(drug) : -Result : PositiveRemark : The patient, carrying genetic variant of hepatic metabolism making her particularly susceptible to oxidative stress, developed an abnormal response to a mild toxic insult, afforded by a combination of agents (oral contraceptives + irbesartan + green tea) that normally would not be able to cause damage. Her particular hepatic metabolism might have further increased the drugs' concentration, favoring the haptenization of liver proteins, eventually leading to the development of an autoimmune hepatitis. *Interaction with a combination of gestodene and 17alpha-ethinylestradiol as oral contraceptive
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : FemaleAge : 42 yrsRoute : Oral administrationDose/Conc.(herb) : 1 g/ die of catechinsDuration : 10 daysType of interaction : PharmacokineticsInteraction with drug : Estradiol*/17 alpha-ethinylestradiolDose/Conc.(drug) : -Result : PositiveRemark : The patient, carrying genetic variant of hepatic metabolism making her particularly susceptible to oxidative stress, developed an abnormal response to a mild toxic insult, afforded by a combination of agents (oral contraceptives + irbesartan + green tea) that normally would not be able to cause damage. Her particular hepatic metabolism might have further increased the drugs' concentration, favoring the haptenization of liver proteins, eventually leading to the development of an autoimmune hepatitis. *Interaction with a combination of gestodene and 17alpha-ethinylestradiol as oral contraceptive
Part Used : ใบActivity : CYP3A4 INDUCTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : FemaleAge : 42 yrsRoute : Oral administrationDose/Conc.(herb) : 1 g/ die of catechinsDuration : 10 daysType of interaction : PharmacokineticsInteraction with drug : Estradiol*/17 alpha-ethinylestradiolDose/Conc.(drug) : -Result : PositiveRemark : The patient, carrying genetic variant of hepatic metabolism making her particularly susceptible to oxidative stress, developed an abnormal response to a mild toxic insult, afforded by a combination of agents (oral contraceptives + irbesartan + green tea) that normally would not be able to cause damage. Her particular hepatic metabolism might have further increased the drugs' concentration, favoring the haptenization of liver proteins, eventually leading to the development of an autoimmune hepatitis. *Interaction with a combination of gestodene and 17alpha-ethinylestradiol as oral contraceptive
