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Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Polyphenon E (PPE)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : AtorvastatinDose/Conc.(drug) : -Result : PositiveRemark : Treatment with combination of PPE and atorvastatin also synergistically decreased the number of viable H1299 and H460 cell. The combination of PPE and atrovastatin was more efficient in reducing the antiapoptotic protein Mcl-1 level and increasing the cleaved caspase-3 and cleaved poly(ADP)-ribose polymerase level than single agent.Note : Data incomplete.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Polyphenon E (PPE)Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 0.25% in drinking fluidDuration : 16 weeksType of interaction : PharmacodynamicsInteraction with drug : AtorvastatinDose/Conc.(drug) : 200 ppm in dietResult : PositiveRemark : The low-dose combinations of PPE and atrovastatin significantly reduced both tumor multiplicity and tumor burden by 56% and 55%, respectively. However the individual agent, PPE or atorvastatin, were not effective inhibiting lung tumorigenesis in tumorigenesis model.Note : Data incomplete.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Polyphenon E (PPE)Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 0.5% in drinking fluidDuration : 16 weeksType of interaction : PharmacodynamicsInteraction with drug : AtorvastatinDose/Conc.(drug) : 400 ppm in dietResult : PositiveRemark : The low-dose combinations of PPE and atrovastatin significantly reduced both tumor multiplicity and tumor burden by 56% and 55%, respectively. However the individual agent, PPE or atorvastatin, were not effective inhibiting lung tumorigenesis in tumorigenesis model.Note : Data incomplete.
