| Synonym |
| Thai / English name |
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 14 (M/F=11/3)N(Treatment) : 14 (M/F=11/3)Sex : Both sexAge : 29+/-8 years (range 19-41 years)Route : Oral administrationDose/Conc.(herb) : 8 oz.Duration : -Type of interaction : PharmacokineticsInteraction with drug : FlurbiprofenDose/Conc.(drug) : 100 mgResult : NegativeRemark : Subject: Healthy volunteers received 100 mg flurbiprofen on 5 occasions in a crossover fashion, with at least 1 week separating the 5 trials. Flurbiprofen was preceded in radom sequence by the following: (1) cranberry juice placebo (8 oz.), (2) cranberry juice (8 oz), (3) brewed tea (8 oz), (4) grape juice (8 oz), and (5) fluconazole, a CYP2C9 inhibitor serving as a positive control, with 8 oz of water. Results: none of the 3 beverages (cranberry juice, grape juice and tea) altered CYP2C9-mediated clearance of flurbiprofen in humans.
Part Used : -Activity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 14 (M/F=11/3)N(Treatment) : 14 (M/F=11/3)Sex : Both sexAge : 29+/-8 years (range 19-41 years)Route : Oral administrationDose/Conc.(herb) : 8 oz.Duration : -Type of interaction : PharmacokineticsInteraction with drug : FlurbiprofenDose/Conc.(drug) : 100 mgResult : NegativeRemark : Subject: Healthy volunteers received 100 mg flurbiprofen on 5 occasions in a crossover fashion, with at least 1 week separating the 5 trials. Flurbiprofen was preceded in radom sequence by the following: (1) cranberry juice placebo (8 oz.), (2) cranberry juice (8 oz), (3) brewed tea (8 oz), (4) grape juice (8 oz), and (5) fluconazole, a CYP2C9 inhibitor serving as a positive control, with 8 oz of water. Results: none of the 3 beverages (cranberry juice, grape juice and tea) altered CYP2C9-mediated clearance of flurbiprofen in humans.
Part Used : -Activity : CYP2C9 INHIBITIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 14 (M/F=11/3)N(Treatment) : 14 (M/F=11/3)Sex : Both sexAge : 29+/-8 years (range 19-41 years)Route : Oral administrationDose/Conc.(herb) : 8 oz.Duration : -Type of interaction : PharmacokineticsInteraction with drug : FlurbiprofenDose/Conc.(drug) : 100 mgResult : NegativeRemark : Subject: Healthy volunteers received 100 mg flurbiprofen on 5 occasions in a crossover fashion, with at least 1 week separating the 5 trials. Flurbiprofen was preceded in radom sequence by the following: (1) cranberry juice placebo (8 oz.), (2) cranberry juice (8 oz), (3) brewed tea (8 oz), (4) grape juice (8 oz), and (5) fluconazole, a CYP2C9 inhibitor serving as a positive control, with 8 oz of water. Results: none of the 3 beverages (cranberry juice, grape juice and tea) altered CYP2C9-mediated clearance of flurbiprofen in humans.
