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Part Used : ไม่ระบุActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : Green teaType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : Catechins inhibit some CYP enzymes and P-gp, but inhibition of CYP enzymes thought to be reason for chemoprotectant effect of tea. Caution with warfarin. Caffeine induces CYP1A2.Note : Data incomplete, data from review article.
Part Used : ไม่ระบุActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : Green teaType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : Catechins inhibit some CYP enzymes and P-gp, but inhibition of CYP enzymes thought to be reason for chemoprotectant effect of tea. Caution with warfarin. Caffeine induces CYP1A2.Note : Data incomplete, data from review article.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Green teaType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : Catechins inhibit some CYP enzymes and P-gp, but inhibition of CYP enzymes thought to be reason for chemoprotectant effect of tea. Caution with warfarin. Caffeine induces CYP1A2.Note : Data incomplete, data from review article.
Part Used : ไม่ระบุActivity : CYP1A2 INDUCTIONSolvent/Active Compound : Green teaType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : Catechins inhibit some CYP enzymes and P-gp, but inhibition of CYP enzymes thought to be reason for chemoprotectant effect of tea. Caution with warfarin. Caffeine induces CYP1A2.Note : Data incomplete, data from review article.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 250N(Treatment) : 126Sex : Both sexAge : 69+/-10 yrs.Route : Oral administrationDose/Conc.(herb) : Consumption of herbs at least 4 times per weekDuration : -Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : Consumption of herbs at least 4 times per week was associated with suboptimal anticoagulation control with warfarin. Patients treated with warfarin should not only be aware of the intake of herbal drugs but also of foods with herbal ingredients such as garlic, ginger, and papaya.Note : Patients with atrial fibrillation (AF) who were prescribed warfarin therapy for at least 6 months before the study were recruited from the medical and cardiac clinics.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : Green teaType of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : MaleAge : 44 yearsRoute : Oral administrationDose/Conc.(herb) : One-half to one gallon per dayDuration : One weekType of interaction : PharmacodynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : The patient had an international normalized ratio (INR) 3.79 after receiving warfarin on entering clinic. Twenty-two days later his INR was 1.367. One month later the patient's INR was 1.14. It was subsequently discovered that the patient began drinking one-half to one gallon per day about one week prior to the INR 1.37. On discontinuation of green tea, the patient's INR increased to 2.55.Note : Data incomplete.
Part Used : ใบActivity : COAGULANT ACTIVITYSolvent/Active Compound : Green teaType of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : MaleAge : 44 yearsRoute : Oral administrationDose/Conc.(herb) : One-half to one gallon per dayDuration : One weekType of interaction : PharmacodynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : The patient had an international normalized ratio (INR) 3.79 after receiving warfarin on entering clinic. Twenty-two days later his INR was 1.367. One month later the patient's INR was 1.14. It was subsequently discovered that the patient began drinking one-half to one gallon per day about one week prior to the INR 1.37. On discontinuation of green tea, the patient's INR increased to 2.55.Note : Data incomplete.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : vitamin KType of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1 (M/F=1/-)N(Treatment) : 1 (M/F=1/-)Sex : MaleAge : 44 years oldRoute : Oral administrationDose/Conc.(herb) : one-half to one gallon of green tea per dayDuration : one weekType of interaction : PharmacodynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : -The patient was receiving warfarin for thromboembolic prophylaxis. The patient had an international normalized ratio (INR) of 3.79 on entering our clinic. Twenty-two days later his INR was 1.37. One month later the patient's INR was 1.14. It was subsequently discovered that the patient began drinking one-half to one gallon of green tea per day about one week prior to the INR of 1.37. On discontinuation of the green tea, the patient's INR increase to 2.55. - Green tea can be a significant source of vitamin K and thus antagonize the effect of warfarin.Note : Data incomplete
Part Used : ไม่ระบุActivity : COAGULANT ACTIVITYSolvent/Active Compound : vitamin KType of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1 (M/F=1/-)N(Treatment) : 1 (M/F=1/-)Sex : MaleAge : 44 years oldRoute : Oral administrationDose/Conc.(herb) : one-half to one gallon of green tea per dayDuration : one weekType of interaction : PharmacodynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : -The patient was receiving warfarin for thromboembolic prophylaxis. The patient had an international normalized ratio (INR) of 3.79 on entering our clinic. Twenty-two days later his INR was 1.37. One month later the patient's INR was 1.14. It was subsequently discovered that the patient began drinking one-half to one gallon of green tea per day about one week prior to the INR of 1.37. On discontinuation of the green tea, the patient's INR increase to 2.55. - Green tea can be a significant source of vitamin K and thus antagonize the effect of warfarin.Note : Data incomplete
