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Part Used : ใบActivity : CYP3A4 INHIBITIONSolvent/Active Compound : green tea extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 25 microgram/mlDuration : 5 minutesType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : - Details of the standardized Green tea extracts: 99.61% Tea polyphenols, 65.38% EGCG, 82.79% Catechins, 1.17% Caffeine, 3.98% Water, 0.18% Sulfated ash. - Results: The degree of CYP3A4 inhibition of Ginkgo biloba was 93.8% and IC50 values of that inhibit CYP3A4-mediated metabolism of midazolam = 9.96 microgram/ml, 95% Cl: 5.41-18.3.Note : The effects of complementary and alternative medicine (CAM) on CYP3A4-mediated metabolism of midazolam and docetaxel were determined in human liver microsomes (HLM), using liquid-chromatography coupled to tandem mass spectrometry (LC-MS/MS).
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : green tea extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 25 microgram/mlDuration : 5 minutesType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : - Details of the standardized Green tea extracts: 99.61% Tea polyphenols, 65.38% EGCG, 82.79% Catechins, 1.17% Caffeine, 3.98% Water, 0.18% Sulfated ash. - Results: The degree of CYP3A4 inhibition of Ginkgo biloba was 93.8% and IC50 values of that inhibit CYP3A4-mediated metabolism of midazolam = 9.96 microgram/ml, 95% Cl: 5.41-18.3.Note : The effects of complementary and alternative medicine (CAM) on CYP3A4-mediated metabolism of midazolam and docetaxel were determined in human liver microsomes (HLM), using liquid-chromatography coupled to tandem mass spectrometry (LC-MS/MS).
Part Used : ไม่ระบุActivity : CYP3A4 INDUCTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : 1 weeksType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : Although single treatments with green tea exts. or grape seed ext. had negligible effects, 1 wk of treatment with them resulted in a significant increase in the ke of i.v. administered midazolam (MDZ), indicating the induction of CYP3A in the liver.Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : 1 weeksType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : Although single treatments with green tea exts. or grape seed ext. had negligible effects, 1 wk of treatment with them resulted in a significant increase in the ke of i.v. administered midazolam (MDZ), indicating the induction of CYP3A in the liver.Note : Data incomplete
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : 1 weeksType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : Although single treatments with green tea exts. or grape seed ext. had negligible effects, 1 wk of treatment with them resulted in a significant increase in the ke of i.v. administered midazolam (MDZ), indicating the induction of CYP3A in the liver.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYP3A4 INHIBITIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : 1 weeksType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : 1 wk of treatment with green tea ext, but not grape seed ext. caused a significant increase in the Cmax and AUCO-infinity of orally administered midazolam (MDZ) without change in the t1/2, suggesting a redn. in CYP3A activity in the small intestines.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYP2C9 INHIBITIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : 1 weeksType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : Strong inhition of these CYP activities was found by the addn. of green tea ext. or grape seed ext. in vitro.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYP2D6 INHIBITIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : 1 weeksType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : Strong inhition of these CYP activities was found by the addn. of green tea ext. or grape seed ext. in vitro.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYP3A4 INHIBITIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : 1 weeksType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : Strong inhition of these CYP activities was found by the addn. of green tea ext. or grape seed ext. in vitro.Note : Data incomplete
