ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ไม่ระบุ

Activity : CYP2D6 INHIBITION

Solvent/Active Compound : decaffeinated green tea

Type of experiment : human

Type of animal : -

Type of study : Open trial

N(Total) : 11

N(Treatment) : 11

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : 4 DGT capsules/day (DGT capsule contained 211+/-25 mg of green tea catechins and <1 mg of caffeine)

Duration : 14 days

Type of interaction : Pharmacokinetics

Interaction with drug : Dextromethorphan*/Dextromethorfan/Dextromorphan

Dose/Conc.(drug) : 30 mg

Result : Negative

Remark : The DMR was 0.053+/-0.045 at baseline and 0.041+/-0.032 after DGT supplementation (P >0.05).

Note : Data incomplete Subject total: healthy volunteers - Results indicate that DGT is unlikely to alter the disposition of medications primarity dependent on the CYP2D6 or CYP3A4 pathways of metabolism. Abbreviation decaffeinated green tea : DGT dextromethorphan metabolic ratios: DMRS alprazola: ALPZ

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