Synonym |
Thai / English name |
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : green tea extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 175 mg kg-1Duration : 4 daysType of interaction : PharmacokineticsInteraction with drug : ClozapineDose/Conc.(drug) : 20 mg kg-1Result : EquivocalRemark : There was no significant difference in the elimination half-life of clozapine between the green tea ext. and saline groups. However, the time to reach peak concn. (Tmax) was significantly increased by green tea ext. The mean total area under the plasma concn.-time curve (AUC0-infinity) and maximal peak plasma concn. (Cmax) of clozapine in the green tea ext. group were significantly lower than those of controls.Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : green tea extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 175 mg kg-1Duration : 4 daysType of interaction : PharmacokineticsInteraction with drug : ClozapineDose/Conc.(drug) : 20 mg kg-1Result : EquivocalRemark : There was no significant difference in the elimination half-life of clozapine between the green tea ext. and saline groups. However, the time to reach peak concn. (Tmax) was significantly increased by green tea ext. The mean total area under the plasma concn.-time curve (AUC0-infinity) and maximal peak plasma concn. (Cmax) of clozapine in the green tea ext. group were significantly lower than those of controls.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYP1A2 INHIBITIONSolvent/Active Compound : green tea exractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : green tea extract 175 mg kg-1Duration : 4 daysType of interaction : PharmacokineticsInteraction with drug : ClozapineDose/Conc.(drug) : 20 mg kg-1Result : PositiveRemark : Green tea extract induced a apprx.2-fold increase in hepatic CYP1A2 levels, while the activity increased slightly (by 10% of control).Note : Data incomplete