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Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : decaffeinated green teaType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 11N(Treatment) : 11Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 4 DGT capsules/day (DGT capsule contained 211+/-25 mg of green tea catechins and <1 mg of caffeine)Duration : 14 daysType of interaction : PharmacokineticsInteraction with drug : AlprazolamDose/Conc.(drug) : 2 mgResult : NegativeRemark : There were no significant differences in ALPZ pharmacokinetics at baseline and after DGT treatment (all P values >/=0.05; max. concn. in plasma, 33+/-8 vs. 34+/-13 ng/mL; time to reach max. concn. in plasma, 1.4+/-1.2 vs. 1.4+/-1.2 h; area under the plasma concn. vs. time curve, 480+/-119 vs. 510 +/- 107 h-ng-ml-1; half-life of elimination, 12.3+/-1.7 vs. 13.1+/-3.4 h).Note : Data incomplete Subject total: healthy volunteers - Results indicate that DGT is unlikely to alter the disposition of medications primarity dependent on the CYP2D6 or CYP3A4 pathways of metabolism. Abbreviation decaffeinated green tea : DGT dextromethorphan metabolic ratios: DMRS alprazola: ALPZ
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : decaffeinated green teaType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 11N(Treatment) : 11Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 4 DGT capsules/day (DGT capsule contained 211+/-25 mg of green tea catechins and <1 mg of caffeine)Duration : 14 daysType of interaction : PharmacokineticsInteraction with drug : AlprazolamDose/Conc.(drug) : 2 mgResult : NegativeRemark : There were no significant differences in ALPZ pharmacokinetics at baseline and after DGT treatment (all P values >/=0.05; max. concn. in plasma, 33+/-8 vs. 34+/-13 ng/mL; time to reach max. concn. in plasma, 1.4+/-1.2 vs. 1.4+/-1.2 h; area under the plasma concn. vs. time curve, 480+/-119 vs. 510 +/- 107 h-ng-ml-1; half-life of elimination, 12.3+/-1.7 vs. 13.1+/-3.4 h).Note : Data incomplete Subject total: healthy volunteers - Results indicate that DGT is unlikely to alter the disposition of medications primarity dependent on the CYP2D6 or CYP3A4 pathways of metabolism. Abbreviation decaffeinated green tea : DGT dextromethorphan metabolic ratios: DMRS alprazola: ALPZ
Part Used : ไม่ระบุActivity : CYP3A4 INHIBITIONSolvent/Active Compound : decaffeinated green teaType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 11N(Treatment) : 11Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 4 DGT capsules/day (DGT capsule contained 211+/-25 mg of green tea catechins and <1 mg of caffeine)Duration : 14 daysType of interaction : PharmacokineticsInteraction with drug : AlprazolamDose/Conc.(drug) : 2 mgResult : NegativeRemark : There were no significant differences in ALPZ pharmacokinetics at baseline and after DGT treatment (all P values >/=0.05; max. concn. in plasma, 33+/-8 vs. 34+/-13 ng/mL; time to reach max. concn. in plasma, 1.4+/-1.2 vs. 1.4+/-1.2 h; area under the plasma concn. vs. time curve, 480+/-119 vs. 510 +/- 107 h-ng-ml-1; half-life of elimination, 12.3+/-1.7 vs. 13.1+/-3.4 h).Note : Data incomplete Subject total: healthy volunteers - Results indicate that DGT is unlikely to alter the disposition of medications primarity dependent on the CYP2D6 or CYP3A4 pathways of metabolism. Abbreviation decaffeinated green tea : DGT dextromethorphan metabolic ratios: DMRS alprazola: ALPZ