ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ไม่ระบุ

Activity : DRUG INTERACTION

Solvent/Active Compound : Glabridin

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : Both sex

Age : -

Route : -

Dose/Conc.(herb) : -

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : Verapamil*/Iproveratril

Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: A rat bilateral in situ brain perfusion These findings indicate that PgP limits the brain penetration of glabridin through the BBB and PgP may cause drug resistance to glabridin (licorice) therapy for CNS diseases and potential drug glabridin interactions. However, further studies are needed to explore the role of other drug transporters (e.g. Mrp1-4) in restricting the brain penetration of glabridin.

Note : PgP = P-glycoprotein BBB = blood-brain barrier Data incomplete

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