Synonym |
Thai / English name |
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : GlabridinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : Both sexAge : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Verapamil*/IproveratrilDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: A rat bilateral in situ brain perfusion These findings indicate that PgP limits the brain penetration of glabridin through the BBB and PgP may cause drug resistance to glabridin (licorice) therapy for CNS diseases and potential drug glabridin interactions. However, further studies are needed to explore the role of other drug transporters (e.g. Mrp1-4) in restricting the brain penetration of glabridin.Note : PgP = P-glycoprotein BBB = blood-brain barrier Data incomplete
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : GlabridinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : Both sexAge : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Verapamil*/IproveratrilDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: A rat bilateral in situ brain perfusion These findings indicate that PgP limits the brain penetration of glabridin through the BBB and PgP may cause drug resistance to glabridin (licorice) therapy for CNS diseases and potential drug glabridin interactions. However, further studies are needed to explore the role of other drug transporters (e.g. Mrp1-4) in restricting the brain penetration of glabridin.Note : PgP = P-glycoprotein BBB = blood-brain barrier Data incomplete