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LEGUMINOSAE (FABACEAE) - PAPILIONOIDEAE Glycyrrhiza glabra L.

Synonym

none ...

Thai / English name

ชะเอมเทศ*

[1-1] of 1 article(s) found

หน้า 1

[1] DIETARY FLAVONOIDS MODULATE CYP2C TO IMPROVE DRUG ORAL BIOAVAILABILITY AND THEIR QUALITATIVE/QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP.
WANG,HONG-JAAN;PAO,LI-HENG;HSIONG,CHENG-HUEI;ET AL.
AAPS JOURNAL 2014 Vol.16(2),258-68 $53202 [Full]

Part Used : ไม่ระบุ
Activity : CYP2C INHIBITION

Solvent/Active Compound : Liquiritin

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 1-100 micromolar

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Tolbutamide
Dose/Conc.(drug) : 1 millimolar

Result : Negative

Remark : Liquiritin failed to inhibit CYP2C activity.

Part Used : ไม่ระบุ
Activity : CYP2C INHIBITION

Solvent/Active Compound : Isoliquiritigenin

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 1-100 micromolar

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Tolbutamide
Dose/Conc.(drug) : 1 millimolar

Result : Positive

Remark : Isoliquiritigenin produced 95.7% CYP2C inhibition at 100 micromolar. However, no significant effect was observed in the presence of 10 and 1 micromolar of this compound.

หน้า 1

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