Part Used : ราก
Activity : PHARMACOKINETIC ALTERATION
Solvent/Active Compound : 18beta-glycyrrhetic acid (18beta-GA)
Type of experiment : in vivo
Type of animal : rat
N(Total) : -
N(Treatment) : -
Route : Oral administration
Dose/Conc.(herb) : A single dose of emodin at 11 mg/kg (0.5% sodium CMC), Digoxin at a dose of 0.25 mg/kg was given to the rats by oral administration 30 min after pre-treatment with inhibitors.
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Digoxin
Dose/Conc.(drug) : -
Remark : Result: Co-administration of digoxin with verapamil or emodin can increase the AUC0-t of digoxin by 55% and 51%, respectively. When digoxin was co-administered with verapamil or 18beta-GA, the Cmax of digoxin was increased by 150% and 58%, respectively. In addition, the volume of distribution (Vd/F) and total body clearance of digoxin (CL/F) of digoxin were both decreased after pretreatment with verapamil or emodin in rats.