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Part Used : รากActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : 18beta-glycyrrhetic acid (18beta-GA)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : A single dose of emodin at 11 mg/kg (0.5% sodium CMC), Digoxin at a dose of 0.25 mg/kg was given to the rats by oral administration 30 min after pre-treatment with inhibitors.Duration : -Type of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : PositiveRemark : Result: Co-administration of digoxin with verapamil or emodin can increase the AUC0-t of digoxin by 55% and 51%, respectively. When digoxin was co-administered with verapamil or 18beta-GA, the Cmax of digoxin was increased by 150% and 58%, respectively. In addition, the volume of distribution (Vd/F) and total body clearance of digoxin (CL/F) of digoxin were both decreased after pretreatment with verapamil or emodin in rats.
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : LidocaineDose/Conc.(drug) : -Result : PositiveRemark : The pharmacokinetic profile of lidocaine was significantly modified in the rats with the herbal pretreatment. Elimination half-lives were shortened by 39%, and total clearance were increased by 59% with the pretreatment of Glycyrrhiza uralensis. In conclusion, Glycyrrhiza uralensis showed induction effect on P450 isozymes. Efficacy and safety profiles of a drug may be affected when the herbal products or herbal prescriptions containing the plant medicine were concomitantly used.Note : Data incomplete
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1 g/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : LidocaineDose/Conc.(drug) : -Result : PositiveRemark : The pharmacokinetic profile of lidocaine was significantly modified in the rats with the herbal pretreatment. Elimination half-lives were shortened by 39%, and total clearance were increased by 59% with the pretreatment of Glycyrrhiza uralensis. In conclusion, Glycyrrhiza uralensis showed induction effect on P450 isozymes. Efficacy and safety profiles of a drug may be affected when the herbal products or herbal prescriptions containing the plant medicine were concomitantly used.Note : Data incomplete
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 3 g/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : LidocaineDose/Conc.(drug) : -Result : PositiveRemark : The pharmacokinetic profile of lidocaine was significantly modified in the rats with the herbal pretreatment. Elimination half-lives were shortened by 39%, and total clearance were increased by 59% with the pretreatment of Glycyrrhiza uralensis. In conclusion, Glycyrrhiza uralensis showed induction effect on P450 isozymes. Efficacy and safety profiles of a drug may be affected when the herbal products or herbal prescriptions containing the plant medicine were concomitantly used.Note : Data incomplete
