| Synonym |
| Thai / English name |
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : 18beta-glycyrrhetic acid (18beta-GA), 18alpha-glycyrrhetic acid (18alpha-GA)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 50 micromolarsDuration : -Type of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : PositiveRemark : Result: The inhibitory effects on P-gp mediated digoxin transport were investigated in MDR1-MDCKII cells. Emodin, 18 beta-GA, DAG, and 20 (S)-GF1 exhibited significant inhibition (> 50%) on P-gp. However, the isomers or analogs of the 4 herbal constituents (chrysophanol, 18alpha-GA, AG, and Rh1) and the remaining tested compounds relatively weak inhibition on digoxin transport in this cell model. The concentraion-dependent inhibition on P-gp-mediated digoxin transport was further investigated for emodin, 18beta-GA, DAG, and 20(S)-GF1. Emodin was the strongest herbal inhibitor of P-gp, followed by 18beta-GA, 20(S)-GF1 and DAG. Consistent with the data obtained from MDR1-MDCKII cells, emodin, 18 beta-GA, DAG, and 20(S)-GF1 significantly inhibited digoxin transport (>50%), while chrysophanol, 18alpha-GA, AG, and Rh1 showed no effects or relatively weak inhibition on P-gp.
Part Used : รากActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : 18beta-glycyrrhetic acid (18beta-GA), 18alpha-glycyrrhetic acid (18alpha-GA)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 50 micromolarsDuration : -Type of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : PositiveRemark : Result: The inhibitory effects on P-gp mediated digoxin transport were investigated in MDR1-MDCKII cells. Emodin, 18 beta-GA, DAG, and 20 (S)-GF1 exhibited significant inhibition (> 50%) on P-gp. However, the isomers or analogs of the 4 herbal constituents (chrysophanol, 18alpha-GA, AG, and Rh1) and the remaining tested compounds relatively weak inhibition on digoxin transport in this cell model. The concentraion-dependent inhibition on P-gp-mediated digoxin transport was further investigated for emodin, 18beta-GA, DAG, and 20(S)-GF1. Emodin was the strongest herbal inhibitor of P-gp, followed by 18beta-GA, 20(S)-GF1 and DAG. Consistent with the data obtained from MDR1-MDCKII cells, emodin, 18 beta-GA, DAG, and 20(S)-GF1 significantly inhibited digoxin transport (>50%), while chrysophanol, 18alpha-GA, AG, and Rh1 showed no effects or relatively weak inhibition on P-gp.
Part Used : รากActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : 18beta-glycyrrhetic acid (18beta-GA)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : A single dose of emodin at 11 mg/kg (0.5% sodium CMC), Digoxin at a dose of 0.25 mg/kg was given to the rats by oral administration 30 min after pre-treatment with inhibitors.Duration : -Type of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : PositiveRemark : Result: Co-administration of digoxin with verapamil or emodin can increase the AUC0-t of digoxin by 55% and 51%, respectively. When digoxin was co-administered with verapamil or 18beta-GA, the Cmax of digoxin was increased by 150% and 58%, respectively. In addition, the volume of distribution (Vd/F) and total body clearance of digoxin (CL/F) of digoxin were both decreased after pretreatment with verapamil or emodin in rats.
Part Used : รากActivity : PHARMACOKINETIC ALTERATIONSolvent/Active Compound : 18beta-glycyrrhetic acid (18beta-GA)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : A single dose of emodin at 11 mg/kg (0.5% sodium CMC), Digoxin at a dose of 0.25 mg/kg was given to the rats by oral administration 30 min after pre-treatment with inhibitors.Duration : -Type of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : PositiveRemark : Result: Co-administration of digoxin with verapamil or emodin can increase the AUC0-t of digoxin by 55% and 51%, respectively. When digoxin was co-administered with verapamil or 18beta-GA, the Cmax of digoxin was increased by 150% and 58%, respectively. In addition, the volume of distribution (Vd/F) and total body clearance of digoxin (CL/F) of digoxin were both decreased after pretreatment with verapamil or emodin in rats.
