| Synonym |
| Thai / English name |
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The selective inhibitor of CYP1A2 alpha-naphthoflavone exhibited the most potent inhibitory activity on enzyme activity with mean IC50 of 0.01 microgram/mL. PC and AL exhibited most potent activity with IC50 values in a similar range of that of the alpha-naphthoflavone (p > 0.05). DM, DL, GM and ZO exhibited moderate potencies (IC50 1.04-9.87 microgram/mL), whereas PI and MF exhibited relatively low potencies (IC50 12.95 and 22.05 microgram/mL, respectively) (Substrate=phenacetin)Note : Piper chaba (PC), Dioscroea membranacea (DI), Dracaenal oureiri (DG), Atractylodes lancea (AL), Plumbago indica (PI), Zingiber officinale (ZO), Myristica fragrans (MF), Garcinia mangostana (GM).
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The inhibitory activity on CYP2C19, mean IC50 of the selective inhibitor nootkatone was 5.64 microgram/mL. The inhibitory activities of PI and DM were classified in the most potent group with potency comparable to that of nootkatone (mean IC50 4.71 and 6.92 microgram/mL, respectively, p > 0.05). PC, DL, MF, AL and ZO exhibited moderate potencies (mean IC50 10.44-17.06 microgram/mL), while GM exhibited the lowest potency (mean IC50 61.75 microgram/mL) (Substrate: Omeprazole)Note : Piper chaba (PC), Dioscroea membranacea (DI), Dracaenal oureiri (DG), Atractylodes lancea (AL), Plumbago indica (PI), Zingiber officinale (ZO), Myristica fragrans (MF), Garcinia mangostana (GM).
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The selective inhibitor quinidine showed the most potent inhibitory activity on CYP2D6 activity with mean IC50 of 0.97 microgram/mL. DM, DL and PI showed the highest inhibitory activities (mean IC50 2.93-9.57 microgram/mL). The potency of inhibitory activity of DM was comparable to that of quinidine (p > 0.05). PC, GM and ZO exhibited moderate potencies (mean IC50 23.40-31.32 microgram/mL), and MF and AL exhibited relatively low potencies (mean IC50 195.83 and 313.51 microgram/mL, respectively). (substrate: dextromethorphan)Note : Piper chaba (PC), Dioscroea membranacea (DI), Dracaenal oureiri (DG), Atractylodes lancea (AL), Plumbago indica (PI), Zingiber officinale (ZO), Myristica fragrans (MF), Garcinia mangostana (GM).
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The selective inhibitor ketoconazole showed the most potent inhibitory activity on CYP3A4 with mean IC50 of 0.23 microgram/mL. PC, DM, DL, PI were most potent with mean IC 1.54-6.43 microgram/mL. PC exhibited similar inhibitory activity to ketoconazole (p > 0.05). GM and ZO exhibitied moderate potencies (mean IC50 11.33 and 11.58 microgram/mL, respectively). MF and AL exhibited relatively low potencies (mean IC50 41.91 and 54.36 microgram/mL, respectively) (substrate:nifedipine)Note : Piper chaba (PC), Dioscroea membranacea (DI), Dracaenal oureiri (DG), Atractylodes lancea (AL), Plumbago indica (PI), Zingiber officinale (ZO), Myristica fragrans (MF), Garcinia mangostana (GM).
