ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ราก

Activity : CYP2C19 INHIBITION

Solvent/Active Compound : ethanol

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : -

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Positive

Remark : The inhibitory activity on CYP2C19, mean IC50 of the selective inhibitor nootkatone was 5.64 microgram/mL. The inhibitory activities of PI and DM were classified in the most potent group with potency comparable to that of nootkatone (mean IC50 4.71 and 6.92 microgram/mL, respectively, p > 0.05). PC, DL, MF, AL and ZO exhibited moderate potencies (mean IC50 10.44-17.06 microgram/mL), while GM exhibited the lowest potency (mean IC50 61.75 microgram/mL) (Substrate: Omeprazole)

Note : Piper chaba (PC), Dioscroea membranacea (DI), Dracaenal oureiri (DG), Atractylodes lancea (AL), Plumbago indica (PI), Zingiber officinale (ZO), Myristica fragrans (MF), Garcinia mangostana (GM).

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