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MYRISTICACEAE Myristica fragrans Houtt.

Synonym

none ...

Thai / English name

จันทน์เทศ*

[1-2] of 4 article(s) found

หน้า 1 2 3 4

[1] ENHANCED CELLULAR UPTAKE OF PACLITAXEL IN THE PRESENCE OF MACELIGNAN, A PHYTOESTROGEN AND ITS IMPLICATION IN CANCER CHEMOTHERAPY.
QIANG F,HAN H
PLANTA MED 2010 Vol.76(12),P285 $32009 [Full]

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : macelignan (phytoestrogen)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 20 micromolar

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Paclitaxel*/Taxol/PTX
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: NCI/ADR-RES cells Results: Macelignan increased the cellular accumulation of paclitaxel by approximately 1.7 fold in NCI/ADR-RES cells overexpressing P-gp, while it did not alter the cellular accumulation of paclitaxel in OVCAR-8 cells lacking P-gp.

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : macelignan (phytoestrogen)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 20 micromolar

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Paclitaxel*/Taxol/PTX
Dose/Conc.(drug) : -

Result : Negative

Remark : Type of experiment: OVCAR-8 cells Results: Macelignan increased the cellular accumulation of paclitaxel by approximately 1.7 fold in NCI/ADR-RES cells overexpressing P-gp, while it did not alter the cellular accumulation of paclitaxel in OVCAR-8 cells lacking P-gp.

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : macelignan (phytoestrogen)

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Non-specified
Dose/Conc.(herb) : 20 micromolar

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Paclitaxel*/Taxol/PTX
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: oral administration of paclitaxel with and without macelignan. Results: The concurrent use of macelignan significantly enhanced the oral exposure of paclitaxel in rats while it did not affect the intravenous pharmacokinetics of paclitaxel, implying that macelignan might be more effective to improve the intestinal absorption rather than reducing hepatic elimination.

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : macelignan (phytoestrogen)

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Non-specified
Dose/Conc.(herb) : 20 micromolar

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Paclitaxel*/Taxol/PTX
Dose/Conc.(drug) : -

Result : Negative

Remark : Type of experiment: intrevanous administration of paclitaxel with and without macelignan. Results: The concurrent use of macelignan significantly enhanced the oral exposure of paclitaxel in rats while it did not affect the intravenous pharmacokinetics of paclitaxel, implying that macelignan might be more effective to improve the intestinal absorption rather than reducing hepatic elimination.

Note : Data incomplete

[2] EFFECTS OF MACE AND NUTMEG ON HUMAN CYTOCHROME P450 3A4 AND 2C9 ACTIVITY.
KIMURA Y,ITO H,HATANO T
BIOL PHARM BULL 2010 Vol.33(12),1977-82 $33078 [Full]

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : Mace

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 100 microgram/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : IC50=3.9 microgram/ml

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : Mace

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 100 microgram/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : IC50=1.1 microgram/ml

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : Nutmeg

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 100 microgram/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : IC50=4.2 microgram/ml

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : Nutmeg

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 100 microgram/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : IC50=2.6 microgram/ml

Part Used : รก
Activity : DRUG INTERACTION

Solvent/Active Compound : Total extract

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 5 micromolar/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Inhibition (%)=77

Part Used : รก
Activity : DRUG INTERACTION

Solvent/Active Compound : Total extract

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 5 micromolar/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Inhibition (%)=90

หน้า 1 2 3 4

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