Synonym |
Thai / English name |
Part Used : ไม่ระบุActivity : CYP3A4 INHIBITIONSolvent/Active Compound : macelignan (phytoestrogen)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.01-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Type of experiment: rat liver microsome Results: The interaction of macelignan with CYP3A4 might be insignificant at the physiologically achievable concentrations.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYP3A4 INHIBITIONSolvent/Active Compound : macelignan (phytoestrogen)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 0.01-100 micromolarDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Type of experiment: human liver microsome Results: The interaction of macelignan with CYP3A4 might be insignificant at the physiologically achievable concentrations.Note : Data incomplete
Part Used : ไม่ระบุActivity : CYP3A4 INHIBITIONSolvent/Active Compound : MaceType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 microgram/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : IC50=3.9 microgram/ml
Part Used : ไม่ระบุActivity : CYP3A4 INHIBITIONSolvent/Active Compound : NutmegType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 microgram/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : IC50=4.2 microgram/ml
Part Used : รกActivity : CYP3A4 INHIBITIONSolvent/Active Compound : Total extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 micromolar/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Inhibition (%)=77
Part Used : รกActivity : CYP3A4 INHIBITIONSolvent/Active Compound : n-HexaneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 micromolar/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Inhibition (%)=71
Part Used : รกActivity : CYP3A4 INHIBITIONSolvent/Active Compound : EtOAcType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 micromolar/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Inhibition (%)=90
Part Used : รกActivity : CYP3A4 INHIBITIONSolvent/Active Compound : n-BuOHType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 micromolar/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Inhibition (%)=44
Part Used : รกActivity : CYP3A4 INHIBITIONSolvent/Active Compound : WaterType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 micromolar/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Inhibition (%)=3
Part Used : เมล็ดActivity : CYP3A4 INHIBITIONSolvent/Active Compound : Total extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 5 micromolar/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Inhibition (%)=63