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MYRISTICACEAE Myristica fragrans Houtt.

Synonym

none ...

Thai / English name

จันทน์เทศ*

[1-1] of 1 article(s) found

หน้า 1 2

[1] EFFECTS OF MACE AND NUTMEG ON HUMAN CYTOCHROME P450 3A4 AND 2C9 ACTIVITY.
KIMURA Y,ITO H,HATANO T
BIOL PHARM BULL 2010 Vol.33(12),1977-82 $33078 [Full]

Part Used : ไม่ระบุ
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : Mace

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 100 microgram/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : IC50=1.1 microgram/ml

Part Used : ไม่ระบุ
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : Nutmeg

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 100 microgram/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : IC50=2.6 microgram/ml

Part Used : รก
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : Total extract

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 5 micromolar/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Inhibition (%)=90

Part Used : รก
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : n-Hexane

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 5 micromolar/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Inhibition (%)=88

Part Used : รก
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : EtOAc

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 5 micromolar/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Inhibition (%)=100

Part Used : รก
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : n-BuOH

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 5 micromolar/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Inhibition (%)=62

Part Used : รก
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : Water

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 5 micromolar/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Inhibition (%)=2

Part Used : เมล็ด
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : Total extract

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 5 micromolar/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Inhibition (%)=79

Part Used : เมล็ด
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : n-Hexane

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 5 micromolar/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Inhibition (%)=88

Part Used : เมล็ด
Activity : CYP2C9 INHIBITION

Solvent/Active Compound : EtOAc

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 5 micromolar/ml

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Inhibition (%)=100

หน้า 1 2

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