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Part Used : เมล็ด

Activity : CYP1A2 INHIBITION

Solvent/Active Compound : ethanol

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : -

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Positive

Remark : The selective inhibitor of CYP1A2 alpha-naphthoflavone exhibited the most potent inhibitory activity on enzyme activity with mean IC50 of 0.01 microgram/mL. PC and AL exhibited most potent activity with IC50 values in a similar range of that of the alpha-naphthoflavone (p > 0.05). DM, DL, GM and ZO exhibited moderate potencies (IC50 1.04-9.87 microgram/mL), whereas PI and MF exhibited relatively low potencies (IC50 12.95 and 22.05 microgram/mL, respectively) (Substrate=phenacetin)

Note : Piper chaba (PC), Dioscroea membranacea (DI), Dracaenal oureiri (DG), Atractylodes lancea (AL), Plumbago indica (PI), Zingiber officinale (ZO), Myristica fragrans (MF), Garcinia mangostana (GM).

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