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Part Used : น้ำมันActivity : DRUG INTERACTIONSolvent/Active Compound : Safflower oilType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : Diet containing 10% of safflower oilDuration : 4 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : -Result : PositiveRemark : In spite of a 20-fold difference in dietay linoleic acid content, the safflower oil group had similar prostaglandin-generating capacities to the saturated fat control group, suggesting tight metabolic control of prostaglandin and their precursors. Concurrent administration of omega-3 fatty acid and indomethacin reduced prostaglandin levels further than those obtainable by diet alone, domonstrating that the diet not results in maximal inhibition.Note : Data incomplete.
Part Used : น้ำมันActivity : PROSTAGLANDIN SYNTHESIS INHIBITIONSolvent/Active Compound : Safflower oilType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : Diet containing 10% of safflower oilDuration : 4 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : -Result : PositiveRemark : In spite of a 20-fold difference in dietay linoleic acid content, the safflower oil group had similar prostaglandin-generating capacities to the saturated fat control group, suggesting tight metabolic control of prostaglandin and their precursors. Concurrent administration of omega-3 fatty acid and indomethacin reduced prostaglandin levels further than those obtainable by diet alone, domonstrating that the diet not results in maximal inhibition.Note : Data incomplete.
