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Part Used : ดอกActivity : DRUG INTERACTIONSolvent/Active Compound : Hydroxysafflor yellow A (HSYA)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntravenousDose/Conc.(herb) : 3.0 mg/kgDuration : 3 daysType of interaction : PharmacokineticsInteraction with drug : Phenacetin*/AcetophenetidinDose/Conc.(drug) : -Result : EquivocalRemark : Drug; On the fourth day, a cocktail solution at a dose of 5 mL/kg, which contained phenacetin (20 mg/kg), tolbutamide (5 mg/kg), dextromethorphan (20 mg/kg) and midazolam (10 mg/kg) in CMC-Na solution, was administered orally to all rats in each group. Blood samples of each rat were collected pre-dose (0 h) and 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 12 h after probe drugs administration. Results; The pharmacokinetic parameters of phenacetin in rats showed no significant difference among LSG, HSG and BCG.Note : T1/2: half-life; Tmax: the time of peak concentration; Cmax: the peak or maximum concentration; AUC(0-infinity): area under a curve extrapolated to infinity; MRT: mean residence time; CL: the total body clearance; BCG: blank control group; LSG: low dosage (3.0 mg/kg/day) and short period (3 days) group; LLG: low dosage and long period (14 days) group; HSG: high dosage (12.0 mg/kg/day) and short period group; HLG: high dosage and long period group.
Part Used : ดอกActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Hydroxysafflor yellow A (HSYA)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntravenousDose/Conc.(herb) : 3.0 mg/kgDuration : 3 daysType of interaction : PharmacokineticsInteraction with drug : Phenacetin*/AcetophenetidinDose/Conc.(drug) : -Result : EquivocalRemark : Drug; On the fourth day, a cocktail solution at a dose of 5 mL/kg, which contained phenacetin (20 mg/kg), tolbutamide (5 mg/kg), dextromethorphan (20 mg/kg) and midazolam (10 mg/kg) in CMC-Na solution, was administered orally to all rats in each group. Blood samples of each rat were collected pre-dose (0 h) and 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 12 h after probe drugs administration. Results; The pharmacokinetic parameters of phenacetin in rats showed no significant difference among LSG, HSG and BCG.Note : T1/2: half-life; Tmax: the time of peak concentration; Cmax: the peak or maximum concentration; AUC(0-infinity): area under a curve extrapolated to infinity; MRT: mean residence time; CL: the total body clearance; BCG: blank control group; LSG: low dosage (3.0 mg/kg/day) and short period (3 days) group; LLG: low dosage and long period (14 days) group; HSG: high dosage (12.0 mg/kg/day) and short period group; HLG: high dosage and long period group.
Part Used : ดอกActivity : CYP1A2 INHIBITIONSolvent/Active Compound : Hydroxysafflor yellow A (HSYA)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntravenousDose/Conc.(herb) : 3.0 mg/kgDuration : 3 daysType of interaction : PharmacokineticsInteraction with drug : Phenacetin*/AcetophenetidinDose/Conc.(drug) : -Result : EquivocalRemark : Drug; On the fourth day, a cocktail solution at a dose of 5 mL/kg, which contained phenacetin (20 mg/kg), tolbutamide (5 mg/kg), dextromethorphan (20 mg/kg) and midazolam (10 mg/kg) in CMC-Na solution, was administered orally to all rats in each group. Blood samples of each rat were collected pre-dose (0 h) and 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 12 h after probe drugs administration. Results; The pharmacokinetic parameters of phenacetin in rats showed no significant difference among LSG, HSG and BCG.Note : T1/2: half-life; Tmax: the time of peak concentration; Cmax: the peak or maximum concentration; AUC(0-infinity): area under a curve extrapolated to infinity; MRT: mean residence time; CL: the total body clearance; BCG: blank control group; LSG: low dosage (3.0 mg/kg/day) and short period (3 days) group; LLG: low dosage and long period (14 days) group; HSG: high dosage (12.0 mg/kg/day) and short period group; HLG: high dosage and long period group.
Part Used : ดอกActivity : DRUG INTERACTIONSolvent/Active Compound : Hydroxysafflor yellow A (HSYA)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntravenousDose/Conc.(herb) : 12.0 mg/kgDuration : 3 daysType of interaction : PharmacokineticsInteraction with drug : Phenacetin*/AcetophenetidinDose/Conc.(drug) : -Result : EquivocalRemark : Drug; On the fourth day, a cocktail solution at a dose of 5 mL/kg, which contained phenacetin (20 mg/kg), tolbutamide (5 mg/kg), dextromethorphan (20 mg/kg) and midazolam (10 mg/kg) in CMC-Na solution, was administered orally to all rats in each group. Blood samples of each rat were collected pre-dose (0 h) and 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 12 h after probe drugs administration. Results; The pharmacokinetic parameters of phenacetin in rats showed no significant difference among LSG, HSG and BCG.Note : T1/2: half-life; Tmax: the time of peak concentration; Cmax: the peak or maximum concentration; AUC(0-infinity): area under a curve extrapolated to infinity; MRT: mean residence time; CL: the total body clearance; BCG: blank control group; LSG: low dosage (3.0 mg/kg/day) and short period (3 days) group; LLG: low dosage and long period (14 days) group; HSG: high dosage (12.0 mg/kg/day) and short period group; HLG: high dosage and long period group.
Part Used : ดอกActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Hydroxysafflor yellow A (HSYA)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntravenousDose/Conc.(herb) : 12.0 mg/kgDuration : 3 daysType of interaction : PharmacokineticsInteraction with drug : Phenacetin*/AcetophenetidinDose/Conc.(drug) : -Result : EquivocalRemark : Drug; On the fourth day, a cocktail solution at a dose of 5 mL/kg, which contained phenacetin (20 mg/kg), tolbutamide (5 mg/kg), dextromethorphan (20 mg/kg) and midazolam (10 mg/kg) in CMC-Na solution, was administered orally to all rats in each group. Blood samples of each rat were collected pre-dose (0 h) and 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 12 h after probe drugs administration. Results; The pharmacokinetic parameters of phenacetin in rats showed no significant difference among LSG, HSG and BCG.Note : T1/2: half-life; Tmax: the time of peak concentration; Cmax: the peak or maximum concentration; AUC(0-infinity): area under a curve extrapolated to infinity; MRT: mean residence time; CL: the total body clearance; BCG: blank control group; LSG: low dosage (3.0 mg/kg/day) and short period (3 days) group; LLG: low dosage and long period (14 days) group; HSG: high dosage (12.0 mg/kg/day) and short period group; HLG: high dosage and long period group.
Part Used : ดอกActivity : CYP1A2 INHIBITIONSolvent/Active Compound : Hydroxysafflor yellow A (HSYA)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntravenousDose/Conc.(herb) : 12.0 mg/kgDuration : 3 daysType of interaction : PharmacokineticsInteraction with drug : Phenacetin*/AcetophenetidinDose/Conc.(drug) : -Result : EquivocalRemark : Drug; On the fourth day, a cocktail solution at a dose of 5 mL/kg, which contained phenacetin (20 mg/kg), tolbutamide (5 mg/kg), dextromethorphan (20 mg/kg) and midazolam (10 mg/kg) in CMC-Na solution, was administered orally to all rats in each group. Blood samples of each rat were collected pre-dose (0 h) and 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 12 h after probe drugs administration. Results; The pharmacokinetic parameters of phenacetin in rats showed no significant difference among LSG, HSG and BCG.Note : T1/2: half-life; Tmax: the time of peak concentration; Cmax: the peak or maximum concentration; AUC(0-infinity): area under a curve extrapolated to infinity; MRT: mean residence time; CL: the total body clearance; BCG: blank control group; LSG: low dosage (3.0 mg/kg/day) and short period (3 days) group; LLG: low dosage and long period (14 days) group; HSG: high dosage (12.0 mg/kg/day) and short period group; HLG: high dosage and long period group.
Part Used : ดอกActivity : DRUG INTERACTIONSolvent/Active Compound : Hydroxysafflor yellow A (HSYA)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntravenousDose/Conc.(herb) : 3.0 mg/kgDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : Phenacetin*/AcetophenetidinDose/Conc.(drug) : -Result : PositiveRemark : Drug; On the eleventh or fifteenth day, a cocktail solution at a dose of 5 mL/kg, which contained phenacetin (20 mg/kg), tolbutamide (5 mg/kg), dextromethorphan (20 mg/kg) and midazolam (10 mg/kg) in CMC-Na solution, was administered orally to all rats in each group. Blood samples of each rat were collected pre-dose (0 h) and 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 12 h after probe drugs administration through the tail vein. Results; After pretreatment with HSYA, the t1/2, Tmax, Cmax, AUC (0- infinity) and MRT (0-infinity) of phenacetin in LLG were increased significantly by 36.2%, 33.3%, 32.9%, 94.6% and 74.9% (P<0.05) compared to those of BCG, CL of phenacetin in LLG was decreased significantly by 46.3% (P<0.05).Note : T1/2: half-life; Tmax: the time of peak concentration; Cmax: the peak or maximum concentration; AUC(0-infinity): area under a curve extrapolated to infinity; MRT: mean residence time; CL: the total body clearance; BCG: blank control group; LSG: low dosage (3.0 mg/kg/day) and short period (3 days) group; LLG: low dosage and long period (14 days) group; HSG: high dosage (12.0 mg/kg/day) and short period group; HLG: high dosage and long period group.
Part Used : ดอกActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Hydroxysafflor yellow A (HSYA)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntravenousDose/Conc.(herb) : 3.0 mg/kgDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : Phenacetin*/AcetophenetidinDose/Conc.(drug) : -Result : PositiveRemark : Drug; On the eleventh or fifteenth day, a cocktail solution at a dose of 5 mL/kg, which contained phenacetin (20 mg/kg), tolbutamide (5 mg/kg), dextromethorphan (20 mg/kg) and midazolam (10 mg/kg) in CMC-Na solution, was administered orally to all rats in each group. Blood samples of each rat were collected pre-dose (0 h) and 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 12 h after probe drugs administration through the tail vein. Results; After pretreatment with HSYA, the t1/2, Tmax, C max, AUC (0- infinity) and MRT (0-infinity) of phenacetin in LLG were increased significantly by 36.2%, 33.3%, 32.9%, 94.6% and 74.9% (P<0.05) compared to those of BCG, CL of phenacetin in LLG was decreased significantly by 46.3% (P<0.05).Note : T1/2: half-life; Tmax: the time of peak concentration; Cmax: the peak or maximum concentration; AUC(0-infinity): area under a curve extrapolated to infinity; MRT: mean residence time; CL: the total body clearance; BCG: blank control group; LSG: low dosage (3.0 mg/kg/day) and short period (3 days) group; LLG: low dosage and long period (14 days) group; HSG: high dosage (12.0 mg/kg/day) and short period group; HLG: high dosage and long period group.
Part Used : ดอกActivity : CYP1A2 INHIBITIONSolvent/Active Compound : Hydroxysafflor yellow A (HSYA)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntravenousDose/Conc.(herb) : 3.0 mg/kgDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : Phenacetin*/AcetophenetidinDose/Conc.(drug) : -Result : PositiveRemark : Drug; On the eleventh or fifteenth day, a cocktail solution at a dose of 5 mL/kg, which contained phenacetin (20 mg/kg), tolbutamide (5 mg/kg), dextromethorphan (20 mg/kg) and midazolam (10 mg/kg) in CMC-Na solution, was administered orally to all rats in each group. Blood samples of each rat were collected pre-dose (0 h) and 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 12 h after probe drugs administration through the tail vein. Results; After pretreatment with HSYA, the t1/2, Tmax, C max, AUC (0- infinity) and MRT (0-infinity) of phenacetin in LLG were increased significantly by 36.2%, 33.3%, 32.9%, 94.6% and 74.9% (P<0.05) compared to those of BCG, CL of phenacetin in LLG was decreased significantly by 46.3% (P<0.05).Note : T1/2: half-life; Tmax: the time of peak concentration; Cmax: the peak or maximum concentration; AUC(0-infinity): area under a curve extrapolated to infinity; MRT: mean residence time; CL: the total body clearance; BCG: blank control group; LSG: low dosage (3.0 mg/kg/day) and short period (3 days) group; LLG: low dosage and long period (14 days) group; HSG: high dosage (12.0 mg/kg/day) and short period group; HLG: high dosage and long period group.
Part Used : ดอกActivity : DRUG INTERACTIONSolvent/Active Compound : Hydroxysafflor yellow A (HSYA)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntravenousDose/Conc.(herb) : 12.0 mg/kgDuration : 14 daysType of interaction : PharmacokineticsInteraction with drug : Phenacetin*/AcetophenetidinDose/Conc.(drug) : -Result : PositiveRemark : Drug; On the eleventh or fifteenth day, a cocktail solution at a dose of 5 mL/kg, which contained phenacetin (20 mg/kg), tolbutamide (5 mg/kg), dextromethorphan (20 mg/kg) and midazolam (10 mg/kg) in CMC-Na solution, was administered orally to all rats in each group. Blood samples of each rat were collected pre-dose (0 h) and 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 12 h after probe drugs administration through the tail vein. Results; The t1/2, Tmax, Cmax, AUC (0- infinity) and MRT (0-infinity) of phenacetin in HLG were increased significantly by 63.8%, 52.6%, 82.6%, 193.5% and 78.7% (P<0.05) compared to those of BCG, CL of phenacetin in HLG was decreased significantly by 46.5% (P<0.05).Note : T1/2: half-life; Tmax: the time of peak concentration; Cmax: the peak or maximum concentration; AUC(0-infinity): area under a curve extrapolated to infinity; MRT: mean residence time; CL: the total body clearance; BCG: blank control group; LSG: low dosage (3.0 mg/kg/day) and short period (3 days) group; LLG: low dosage and long period (14 days) group; HSG: high dosage (12.0 mg/kg/day) and short period group; HLG: high dosage and long period group.
