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| Thai / English name |
Part Used : เหง้าActivity : CYCLOOXYGENASE 2 INHIBITIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100 mg/kg dailyDuration : 3 wksType of interaction : P.Kinetics & P.DynamicsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : the organic extracts of ginger are highly effective at inhibiting production of prostaglandin E2 and these compounds appear to not only inhibit COX-2 enzyme activity, but are also able to alter COX-2 mRNA levels, suggesting at least two sites of action. The inhibitory effect of ginger extract on the apoptotic cell death as indicated by inhibition of caspase-3 activity may results from the relive of the oxidative stress and local inflammation. All the studied parameters showed that pre-conditioning of the rats by treatment with ethanolic extract of ginger for 3 weeks prior to BB-treatment appears to protect rats against BB-induced liver damage.Note : The five groups are; Group I: (control group): rats received 0.2 ml dimethyl sulphoxide (DMSO) by gavages as vehicle. Group II: (BB-treated group): received bromobenzene (BB) at a dose of 460 mg/kg BW by intragastric intubation, daily for 7 days. Group III (G100): the rats were pre-treated with 100 mg/kg BW ethanolic ginger extract by intragastric intubation, daily for 3 weeks and treated with BB during the third week. Group IV (G200): the rats were pre-treated with ethanolic ginger extract (200 mg/kg BW) daily for 3 weeks and treated with BB during the third week. Group V (G300): the rats were pre-treated with ethanolic ginger extract (300 mg/kg BW) daily for 3 weeks and treated with BB during the third week.
Part Used : เหง้าActivity : CYCLOOXYGENASE 2 INHIBITIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 200 mg/kg dailyDuration : 3 wksType of interaction : P.Kinetics & P.DynamicsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : the organic extracts of ginger are highly effective at inhibiting production of prostaglandin E2 and these compounds appear to not only inhibit COX-2 enzyme activity, but are also able to alter COX-2 mRNA levels, suggesting at least two sites of action. The inhibitory effect of ginger extract on the apoptotic cell death as indicated by inhibition of caspase-3 activity may results from the relive of the oxidative stress and local inflammation. All the studied parameters showed that pre-conditioning of the rats by treatment with ethanolic extract of ginger for 3 weeks prior to BB-treatment appears to protect rats against BB-induced liver damage.Note : The five groups are; Group I: (control group): rats received 0.2 ml dimethyl sulphoxide (DMSO) by gavages as vehicle. Group II: (BB-treated group): received bromobenzene (BB) at a dose of 460 mg/kg BW by intragastric intubation, daily for 7 days. Group III (G100): the rats were pre-treated with 100 mg/kg BW ethanolic ginger extract by intragastric intubation, daily for 3 weeks and treated with BB during the third week. Group IV (G200): the rats were pre-treated with ethanolic ginger extract (200 mg/kg BW) daily for 3 weeks and treated with BB during the third week. Group V (G300): the rats were pre-treated with ethanolic ginger extract (300 mg/kg BW) daily for 3 weeks and treated with BB during the third week.
Part Used : เหง้าActivity : CYCLOOXYGENASE 2 INHIBITIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 300 mg/kg dailyDuration : 3 wksType of interaction : P.Kinetics & P.DynamicsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : the organic extracts of ginger are highly effective at inhibiting production of prostaglandin E2 and these compounds appear to not only inhibit COX-2 enzyme activity, but are also able to alter COX-2 mRNA levels, suggesting at least two sites of action. The inhibitory effect of ginger extract on the apoptotic cell death as indicated by inhibition of caspase-3 activity may results from the relive of the oxidative stress and local inflammation. All the studied parameters showed that pre-conditioning of the rats by treatment with ethanolic extract of ginger for 3 weeks prior to BB-treatment appears to protect rats against BB-induced liver damage.Note : The five groups are; Group I: (control group): rats received 0.2 ml dimethyl sulphoxide (DMSO) by gavages as vehicle. Group II: (BB-treated group): received bromobenzene (BB) at a dose of 460 mg/kg BW by intragastric intubation, daily for 7 days. Group III (G100): the rats were pre-treated with 100 mg/kg BW ethanolic ginger extract by intragastric intubation, daily for 3 weeks and treated with BB during the third week. Group IV (G200): the rats were pre-treated with ethanolic ginger extract (200 mg/kg BW) daily for 3 weeks and treated with BB during the third week. Group V (G300): the rats were pre-treated with ethanolic ginger extract (300 mg/kg BW) daily for 3 weeks and treated with BB during the third week.
