| Synonym |
| Thai / English name |
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12N(Treatment) : 12Sex : MaleAge : 20-36 yrsRoute : Oral administrationDose/Conc.(herb) : 3 tablets x 3 times dailyDuration : 1 week with at least 14-day washoutType of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : There were no significant changes observed in the pharmacokinetic parameters of S- or R-warfarin in healthy male subjects following treatment with ginkgo or ginger. The urinary excretion rate of S-7-hydroxywarfarin after administration of warfarin alone was no significant difference following treatment with either ginkgo or ginger.Note : Each ginger tablet containing 0.4 g of ginger rhizome powder Each Gingko tablet equivalent to 2 g of Ginkgo biloba leaf (9.6 mg of ginkgo flavonglycosides, 2.4 mg of ginkgolides and bilobalide)
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 12N(Treatment) : 12Sex : MaleAge : 20-36 yrsRoute : Oral administrationDose/Conc.(herb) : 3 tablets x 3 times dailyDuration : 1 week with at least 14-day washoutType of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : There were no significant changes observed in the pharmacokinetic parameters of S- or R-warfarin in healthy male subjects following tretment with ginkgo or ginger. The urinary excretion rate of S-7-hydroxywarfarin after administration of warfarin alone was no significant difference following treatment with either ginkgo or ginger.Note : Each ginger tablet containing 0.4 g of ginger rhizome powder Each Gingko tablet equivalent to 2 g of Ginkgo biloba leaf (9.6 mg of ginkgo flavonglycosides, 2.4 mg of ginkgolides and bilobalide)
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 24N(Treatment) : 24Sex : MaleAge : 26 +/- 5 yearsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : WarfarinDose/Conc.(drug) : 25 mgResult : NegativeRemark : Coadministration with either ginkgo or ginger with warfarin did not affect the pharmacokinetics or pharmacodynamics of S-warfarin.Note : Type of clinical study: randomized, open-label, controlled, 3-treatment, and 3-sequence crossover studies with at least a 14-day washout period between study periods of dosing. Subjects: healthy male subjects received a single 25 mg dose warfarin with or without pretreatment with Commission E19 recommended daily doses of St John's wort, Asian ginseng (Panax ginseng), ginkgo (Ginkgo biloba), or ginger from commercially available products of known quality.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 24N(Treatment) : 24Sex : MaleAge : 26 +/- 5 yearsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : WarfarinDose/Conc.(drug) : 25 mgResult : NegativeRemark : Coadministration with either ginkgo or ginger with warfarin did not affect the pharmacokinetics or pharmacodynamics of S-warfarin.Note : Type of clinical study: randomized, open-label, controlled, 3-treatment, and 3-sequence crossover studies with at least a 14-day washout period between study periods of dosing. Subjects: healthy male subjects received a single 25 mg dose warfarin with or without pretreatment with Commission E19 recommended daily doses of St John's wort, Asian ginseng (Panax ginseng), ginkgo (Ginkgo biloba), or ginger from commercially available products of known quality.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 20N(Treatment) : 20Sex : Both sexAge : 25-60 yrRoute : Oral administrationDose/Conc.(herb) : 1 g of ginger with 10 mg nifedipine, twice dailyDuration : 1 weekType of interaction : PharmacodynamicsInteraction with drug : NifedipineDose/Conc.(drug) : -Result : PositiveRemark : Phase I: the normal volunteers were administered both ginger and nifedipine in combination, it was observed that the higher percentage inhibition of platelet aggregation induced by collagen, ADP and epinephrine were 79.8%, 75.2% and 69.3%, resp. The results indicated that ginger could potentiate the anti-platelet aggregation of nifedipine.Note : Thie study departed into 2 phases. Phase I: normal volunteer, Phase II: hypertensive patient (10) - All results were similar but higher in phase II of the study.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 20N(Treatment) : 20Sex : Both sexAge : 35-60 yrRoute : Oral administrationDose/Conc.(herb) : 1 g of ginger with 10 mg nifedipine, twice dailyDuration : 1 weekType of interaction : PharmacodynamicsInteraction with drug : NifedipineDose/Conc.(drug) : -Result : PositiveRemark : Phase I: study in hypertensive patients showed that the percentage of inhibition of values with the three agonist was higher (64.2%, 63.8% and 61.1%, resp.) after the treatment with the combination of nifedipone and ginger. The results indicated that ginger could potentiate the anti-platelet aggregation of nifedipine.Note : Thie study departed into 2 phases. Phase I: normal volunteer, Phase II: hypertensive patient (10) - All results were similar but higher in phase II of the study.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : 95% EthanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 50 mg/mlDuration : -Type of interaction : PharmacodynamicsInteraction with drug : ClarithromycinDose/Conc.(drug) : -Result : PositiveRemark : Ginger extract + Clarithomycin combination exhibited a synergic or additive effect. Ginger extract + Clarithomycin combination inhibited the growth of Helicobacter pylori strains at a lower concentration than when the single drugs were assayed separately. 18/25 strains showed MIC values of Clarithomycin lowered with the median of reduction of 12-fold (rand 4- to 256- fole) for ginger extracts + Clarithomycin.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : Ginger extract (selected Chinese ginger)Type of experiment : humanType of animal : -Type of study : Double-blind trialN(Total) : 56N(Treatment) : -Sex : Both sexAge : 66 yrs (mean) (24-87 yrs)Route : Oral administrationDose/Conc.(herb) : 170 mg ginger extract tidDuration : 3 wksType of interaction : Non-specifiedInteraction with drug : Ibuprofen*/Para-isobutylhydratropic acidDose/Conc.(drug) : 400 mg. tid (maximum 3 g. daily)Result : NegativeRemark : A ranking of efficacy of the three treatment periods: lbuprofen>ginger extract>placebo was found for visual analogue scale of pain. In the cross-over study, no significant difference between placebo and ginger extract could be demonstrated while explorative tests of differences in the first treatment period showed a better effect of both Ibuprofen and ginger extract than placebo.Note : Ginger extract was compared to placebo and lbuprofen in patients with osteoarthritis of the hip or knee in a controlled, double blind, double dummy, cross-over study with a wash-out period of one week followed by three treatment periods in a randomized sequence, each of three weeks duration.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : Ginger extract (selected Chinese ginger)Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 56N(Treatment) : -Sex : Both sexAge : 66 yrs (mean) (24-87 yrs)Route : Oral administrationDose/Conc.(herb) : 170 mg ginger extract tidDuration : 3 wksType of interaction : Non-specifiedInteraction with drug : Ibuprofen*/Para-isobutylhydratropic acidDose/Conc.(drug) : 400 mg. tid (maximum 3 g. daily)Result : NegativeRemark : A ranking of efficacy of the three treatment periods: lbuprofen>ginger extract>placebo was found for visual analogue scale of pain. In the cross-over study, no significant difference between placebo and ginger extract could be demonstrated while explorative tests of differences in the first treatment period showed a better effect of both Ibuprofen and ginger extract than placebo.Note : Ginger extract was compared to placebo and lbuprofen in patients with osteoarthritis of the hip or knee in a controlled, double blind, double dummy, cross-over study with a wash-out period of one week followed by three treatment periods in a randomized sequence, each of three weeks duration.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 10N(Treatment) : 10Sex : Both sexAge : 25-60 yearsRoute : Oral administrationDose/Conc.(herb) : 1 gDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : NifedipineDose/Conc.(drug) : 10 mgResult : PositiveRemark : Subjects: normal volunteers Results: When the volunteers were administered both ginger and nifedipine in combination, it was observed that the percentage inhibition of platelet aggregation induced by collagen, ADP and epinephrine were 79.8%, 75.2%, 69.3% respectively. These results suggested that ginger and nifedipine possessed synergistic effect on anti-platelet aggregation in normal volunteer.
