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Part Used : เหง้าActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12N(Treatment) : 12Sex : MaleAge : 20-36 yrsRoute : Oral administrationDose/Conc.(herb) : 3 tablets x 3 times dailyDuration : 1 week with at least 14-day washoutType of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : There were no significant changes observed in the pharmacokinetic parameters of S- or R-warfarin in healthy male subjects following treatment with ginkgo or ginger. The urinary excretion rate of S-7-hydroxywarfarin after administration of warfarin alone was no significant difference following treatment with either ginkgo or ginger.Note : Each ginger tablet containing 0.4 g of ginger rhizome powder Each Gingko tablet equivalent to 2 g of Ginkgo biloba leaf (9.6 mg of ginkgo flavonglycosides, 2.4 mg of ginkgolides and bilobalide)
Part Used : เหง้าActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 12N(Treatment) : 12Sex : MaleAge : 20-36 yrsRoute : Oral administrationDose/Conc.(herb) : 3 tablets x 3 times dailyDuration : 1 week with at least 14-day washoutType of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : There were no significant changes observed in the pharmacokinetic parameters of S- or R-warfarin in healthy male subjects following treatment with ginkgo or ginger. The urinary excretion rate of S-7-hydroxywarfarin after administration of warfarin alone was no significant difference following treatment with either ginkgo or ginger.Note : Each ginger tablet containing 0.4 g of ginger rhizome powder Each Gingko tablet equivalent to 2 g of Ginkgo biloba leaf (9.6 mg of ginkgo flavonglycosides, 2.4 mg of ginkgolides and bilobalide)
Part Used : รากActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Ginger juice/ 6-gingerolType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : ginger juice 5 mL/kg (contain 5.2 mg/kg) combination with CyclosporineDuration : concomitantlyType of interaction : PharmacokineticsInteraction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyADose/Conc.(drug) : -Result : PositiveRemark : The results indicated that concomitant intake of ginger juice and its administration 2 hours before cyclosporine significantly decrease Cmax of cyclosporine by 70.9% and 51.4% and reduced AUC0-540 by 63.1% and 40.3%, respectively
Part Used : รากActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Ginger juiceType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : ginger juice 5 mL/kg combination with CyclosporineDuration : 2 h before administration of cyclosporineType of interaction : PharmacokineticsInteraction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyADose/Conc.(drug) : -Result : PositiveRemark : The results indicated that concomitant intake of ginger juice and its administration 2 hours before cyclosporine significantly decrease Cmax of cyclosporine by 70.9% and 51.4% and reduced AUC0-540 by 63.1% and 40.3%, respectively
Part Used : รากActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Ginger juiceType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : ginger juice 5 mL/kg combination with CyclosporineDuration : 2 h before i.v. of cyclosporineType of interaction : PharmacokineticsInteraction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyADose/Conc.(drug) : -Result : PositiveRemark : The results show that ginger juice administration 2 hours before intravenous cyclosporine has no effect on cyclosporine treatment.
Part Used : รากActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : TrikatuType of experiment : in vivoType of animal : otherType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 2 g/kg dailyDuration : 15 daysType of interaction : PharmacokineticsInteraction with drug : PefloxacinDose/Conc.(drug) : -Result : PositiveRemark : The mean plasma concentrations of pefloxacin were consistently lower in trikatu treated goats up to 2 h compared with control animal. The bioavailability of the drug was also significantly higher in trikatu treated goats (44.18+/-2.90% against 38.33 +/-1.80% incontrol animals). Prior treatment of the goats with trikatu significantly reduced the elimination half-life (t1/2Beta) and the zero time intercept of the elimination phase. The indicators of drug distribution in the body i.e. apparent volume of distribution and volume of distribution based on the zero time plasma drug concentration intercept of the elimination phase were significantly higher in the trikatu treated goats.Note : Trikatu prepared from equal parts of Piper longum, Piper nigrum and Zingiber officinale. Type of animal = goat
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mL/kg for ginger juiceDuration : Single administrationType of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : The AUC values of tacrolimus in the rat pre-treated with grapefruit juice, ginger juice, and turmeric juice were significantly larger than those pre-treated with water. These AUC values were almost equal to the values for those pre-treated with 100% pomelo juice.
Part Used : เหง้าActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : waterType of experiment : in vivoType of animal : rabbitType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 4 ml/kgDuration : 30 mins prior to drug administrationType of interaction : PharmacokineticsInteraction with drug : PefloxacinDose/Conc.(drug) : -Result : PositiveRemark : Ginger increased the maximal concentration of pefloxacin from 2.55+/-0.794 when administered alone to 2.96+/-0.746 when administered witn ginger showing a 16.00% increase in the absorbed drug. The prior administration of ginger to the rabbits lead to significant increases in AUC and AUMC of pefloxacin for 72.34% and 91.91% change, respectively. The half-life of pefloxacin produced a marginally significant 56.08% increase in the presence of ginger. Furthermore, the clearance of pefloxcin and its volume of distribution were significantly decreased when administered in the presence of ginger.Note : The study was conduced into 2 phases. In phase I, rabbits were given only Pefloxacin (100 mg/kg) and phase II, the rabbits were given 4 ml/kg of ginger extract 30 mins prior to drug administration. The ginger extract prepared from the cold maceration of 20 g powder with 250 ml water.
Part Used : เหง้าActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : waterType of experiment : in vivoType of animal : rabbitType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1 ml/kg dailyDuration : 3 days with 2-week washout periodType of interaction : PharmacokineticsInteraction with drug : MetronidazoleDose/Conc.(drug) : -Result : PositiveRemark : The peak (Cmax) in the plasma concentration-time curve of metronidazole plus ginger occurred about 4h while metronidazole alone was in 2h post administration, indicated that ginger may have caused delay in the rate of absorption of oral metronidazole. The metronidazole clearance and the elimination rate were reduced in metronidazole plus ginger group (phase II)Note : The study design into 2 phases. In phase I, rabbits were given only metronidazole and phase II, the rabbits were given 1 ml/kg of ginger extract per oral daily for 3 days and immediately given 3 mg/kg metronidazole per oral on the third day.
Part Used : ไม่ระบุActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Ginger extract 25 mgDuration : -Type of interaction : PharmacokineticsInteraction with drug : SimvastatinDose/Conc.(drug) : 20 mgResult : PositiveRemark : A capsule formulation was obtained by combining 41.3 mg delayed-release simvastatin pellets (simvastatin dose 20 mg), as a drug transporter substrate, with 75 mg of pellets containing ginger extract (ginger extract dose 25 mg).Note : Data incomplete
