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Part Used : เหง้า

Activity : P-GLYCOPROTEIN BINDING ACTIVITY

Solvent/Active Compound : 6-shogaoland 6-, 8-, and 10-gingerol

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : -

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Positive

Remark : 10-shogaol, 1-dehydro-6-gingerdione, and particularly the whole lipophilic ginger extract (Ki = 11.6 microgram/ml) partially activate the 5-HT1A receptor (20-60% of maximal activation) 8- and 10 gingerol, 8-shogaol, and 6-dihydroparadol all behaved as weak partial agonist. In addition, the intestinal absorption of gingerols and shogaols was simulated and their interaction with P-glycoprotein were measured, suggesting a favourable pharmacokinetic profile for the 5-HT1A active compounds.

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