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Part Used : เหง้าActivity : CYP1A2 INHIBITIONSolvent/Active Compound : 60% ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Herbal solution (100 microlitre, seven different concentrations for each herb ranging from 4 to 28000 microgram/ml in 4% ethanol)Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The IC50 constants of ginger extract for CYP1A2, CYP2D6, and CYP3A4 inhibition were 320+/-41, 445+/-35, and 565+/-16 microgram/ml, respectively.
Part Used : เหง้าActivity : CYP1A2 INHIBITIONSolvent/Active Compound : ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The selective inhibitor of CYP1A2 alpha-naphthoflavone exhibited the most potent inhibitory activity on enzyme activity with mean IC50 of 0.01 microgram/mL. PC and AL exhibited most potent activity with IC50 values in a similar range of that of the alpha-naphthoflavone (p > 0.05). DM, DL, GM and ZO exhibited moderate potencies (IC50 1.04-9.87 microgram/mL), whereas PI and MF exhibited relatively low potencies (IC50 12.95 and 22.05 microgram/mL, respectively) (Substrate=phenacetin)Note : Piper chaba (PC), Dioscroea membranacea (DI), Dracaenal oureiri (DG), Atractylodes lancea (AL), Plumbago indica (PI), Zingiber officinale (ZO), Myristica fragrans (MF), Garcinia mangostana (GM).
Part Used : ไม่ระบุActivity : CYP1A2 INHIBITIONSolvent/Active Compound : Crude ethanolic extractsType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark :Note : Data incomplete The aim of study was investigated four crude extracts with promising anticancer activity against chalangiocarcinoma i. e. extracts of Atractylodes lancea, Zingiber officinale, Piper chaba and Pra-sa-Prao-Yhai formulation.
