ZINGIBERACEAE Zingiber officinale  Roscoe

 Synonym

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 Thai / English name

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[1-2] of 5 article(s) found

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[1] PROTECTIVE EFFECT OF GINGER EXTRACT AGAINST BROMOBENZENE-INDUCED HEPATOTOXICITY IN MALE RAT.
EL-SHARAKY AS,NEWAIRY AA,KAMEL MA,ET AL.
FOOD CHEM TOXICOL 2009 Vol.47(7),1584-90  $24120 [Full]

Part Used : เหง้า
Activity : CYTOCHROME P-450 INHIBITION
Solvent/Active Compound : -
Type of experiment : in vivo
Type of animal : rat
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : Oral administration
Dose/Conc.(herb) : 100 mg/kg daily
Duration : 3 wks
Type of interaction : P.Kinetics & P.Dynamics
Interaction with drug : -
Dose/Conc.(drug) : -
Result : Positive
Remark : the organic extracts of ginger are highly effective at inhibiting production of prostaglandin E2 and these compounds appear to not only inhibit COX-2 enzyme activity, but are also able to alter COX-2 mRNA levels, suggesting at least two sites of action. The inhibitory effect of ginger extract on the apoptotic cell death as indicated by inhibition of caspase-3 activity may results from the relive of the oxidative stress and local inflammation. All the studied parameters showed that pre-conditioning of the rats by treatment with ethanolic extract of ginger for 3 weeks prior to BB-treatment appears to protect rats against BB-induced liver damage.
Note : The five groups are; Group I: (control group): rats received 0.2 ml dimethyl sulphoxide (DMSO) by gavages as vehicle. Group II: (BB-treated group): received bromobenzene (BB) at a dose of 460 mg/kg BW by intragastric intubation, daily for 7 days. Group III (G100): the rats were pre-treated with 100 mg/kg BW ethanolic ginger extract by intragastric intubation, daily for 3 weeks and treated with BB during the third week. Group IV (G200): the rats were pre-treated with ethanolic ginger extract (200 mg/kg BW) daily for 3 weeks and treated with BB during the third week. Group V (G300): the rats were pre-treated with ethanolic ginger extract (300 mg/kg BW) daily for 3 weeks and treated with BB during the third week.

Part Used : เหง้า
Activity : CYTOCHROME P-450 INHIBITION
Solvent/Active Compound : -
Type of experiment : in vivo
Type of animal : rat
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : Oral administration
Dose/Conc.(herb) : 200 mg/kg daily
Duration : 3 wks
Type of interaction : P.Kinetics & P.Dynamics
Interaction with drug : -
Dose/Conc.(drug) : -
Result : Positive
Remark : the organic extracts of ginger are highly effective at inhibiting production of prostaglandin E2 and these compounds appear to not only inhibit COX-2 enzyme activity, but are also able to alter COX-2 mRNA levels, suggesting at least two sites of action. The inhibitory effect of ginger extract on the apoptotic cell death as indicated by inhibition of caspase-3 activity may results from the relive of the oxidative stress and local inflammation. All the studied parameters showed that pre-conditioning of the rats by treatment with ethanolic extract of ginger for 3 weeks prior to BB-treatment appears to protect rats against BB-induced liver damage.
Note : The five groups are; Group I: (control group): rats received 0.2 ml dimethyl sulphoxide (DMSO) by gavages as vehicle. Group II: (BB-treated group): received bromobenzene (BB) at a dose of 460 mg/kg BW by intragastric intubation, daily for 7 days. Group III (G100): the rats were pre-treated with 100 mg/kg BW ethanolic ginger extract by intragastric intubation, daily for 3 weeks and treated with BB during the third week. Group IV (G200): the rats were pre-treated with ethanolic ginger extract (200 mg/kg BW) daily for 3 weeks and treated with BB during the third week. Group V (G300): the rats were pre-treated with ethanolic ginger extract (300 mg/kg BW) daily for 3 weeks and treated with BB during the third week.

Part Used : เหง้า
Activity : CYTOCHROME P-450 INHIBITION
Solvent/Active Compound : -
Type of experiment : in vivo
Type of animal : rat
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : Oral administration
Dose/Conc.(herb) : 300 mg/kg daily
Duration : 3 wks
Type of interaction : P.Kinetics & P.Dynamics
Interaction with drug : -
Dose/Conc.(drug) : -
Result : Positive
Remark : the organic extracts of ginger are highly effective at inhibiting production of prostaglandin E2 and these compounds appear to not only inhibit COX-2 enzyme activity, but are also able to alter COX-2 mRNA levels, suggesting at least two sites of action. The inhibitory effect of ginger extract on the apoptotic cell death as indicated by inhibition of caspase-3 activity may results from the relive of the oxidative stress and local inflammation. All the studied parameters showed that pre-conditioning of the rats by treatment with ethanolic extract of ginger for 3 weeks prior to BB-treatment appears to protect rats against BB-induced liver damage.
Note : The five groups are; Group I: (control group): rats received 0.2 ml dimethyl sulphoxide (DMSO) by gavages as vehicle. Group II: (BB-treated group): received bromobenzene (BB) at a dose of 460 mg/kg BW by intragastric intubation, daily for 7 days. Group III (G100): the rats were pre-treated with 100 mg/kg BW ethanolic ginger extract by intragastric intubation, daily for 3 weeks and treated with BB during the third week. Group IV (G200): the rats were pre-treated with ethanolic ginger extract (200 mg/kg BW) daily for 3 weeks and treated with BB during the third week. Group V (G300): the rats were pre-treated with ethanolic ginger extract (300 mg/kg BW) daily for 3 weeks and treated with BB during the third week.

[2] CYTOCHROME P450 INHIBITORY POTENTIAL AND RP-HPLC STANDARDIZATION OF TRIKATU—A RASAYANA FROM INDIAN AYURVEDA.
RANJIT K. HARWANSH,KAKALI MUKHERJEE,SANTANU BHADRA,ET AL.
J ETHNOPHARMACOL 2014 Vol.153(),674-81  $51721 [Full]

Part Used : เหง้า
Activity : CYTOCHROME P-450 INHIBITION
Solvent/Active Compound : Ethanol
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 100 micrograms/mL
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Result : Positive
Remark : Results: Extract of the formulations and its ingredients had higher solubility in DMSO than ethanol. It illustrated the highest percentage of inhibition: 37.54+/-3.12% (Trikatu marketed formulation), 35.12+/-2.31% (Trikatu laboratory formulation), 33.23+/-2.56% (6-gingerol), 31.36+/-3.42% (piperine), 17.35+/+1.50% (Zingiber officinale), 20.21+/-1.86% (Piper longum), and 16.67+/-2.83% (Piper nigrum). Lowest inhibition (24.81+/-2.57% and 26.38+/-2.57%) of piperine and 6-gingerol was observed with ethanol.
Note : Type of experiment: rat liver microsomes. The amount of 6-gingerol present in extract of Zingiber officinal, Trikatumarketed formulation and Trikatu laboratory formulation was estimated to be about 6.21+/-1.03%, 5.3+/-1.21% and 4.95+/-2.34% (w/w), respectively. Piperine was found to be 7.31+/-2.36% (Piper longum), 8.41+/-2.54% (Piper nigrum), 7.89+/-2.12% (Trikatu marketed formulation) and 6.70+/-2.13% (w/w) (Trikatu laboratory formulation).

Part Used : เหง้า
Activity : CYTOCHROME P-450 INHIBITION
Solvent/Active Compound : 6-gingerol ethanol
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 6-gingerol ethanol 10 micrograms/mL
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Result : Positive
Remark : Results: Extract of the formulations and its ingredients had higher solubility in DMSO than ethanol. It illustrated the highest percentage of inhibition: 37.54+/-3.12% (Trikatu marketed formulation), 35.12+/-2.31% (Trikatu laboratory formulation), 33.23+/-2.56% (6-gingerol), 31.36+/-3.42% (piperine), 17.35+/+1.50% (Zingiber officinale), 20.21+/-1.86% (Piper longum), and 16.67+/-2.83% (Piper nigrum). Lowest inhibition (24.81+/-2.57% and 26.38+/-2.57%) of piperine and 6-gingerol was observed with ethanol.
Note : Type of experiment: rat liver microsomes. The amount of 6-gingerol present in extract of Zingiber officinal, Trikatumarketed formulation and Trikatu laboratory formulation was estimated to be about 6.21+/-1.03%, 5.3+/-1.21% and 4.95+/-2.34% (w/w), respectively. Piperine was found to be 7.31+/-2.36% (Piper longum), 8.41+/-2.54% (Piper nigrum), 7.89+/-2.12% (Trikatu marketed formulation) and 6.70+/-2.13% (w/w) (Trikatu laboratory formulation).

Part Used : เหง้า
Activity : CYTOCHROME P-450 INHIBITION
Solvent/Active Compound : DMSO (Dimethyl Sulfoxide)
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 100 micrograms/mL
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Result : Positive
Remark : Results: Extract of the formulations and its ingredients had higher solubility in DMSO than ethanol. It illustrated the highest percentage of inhibition: 37.54+/-3.12% (Trikatu marketed formulation), 35.12+/-2.31% (Trikatu laboratory formulation), 33.23+/-2.56% (6-gingerol), 31.36+/-3.42% (piperine), 17.35+/+1.50% (Zingiber officinale), 20.21+/-1.86% (Piper longum), and 16.67+/-2.83% (Piper nigrum). Lowest inhibition (24.81+/-2.57% and 26.38+/-2.57%) of piperine and 6-gingerol was observed with ethanol.
Note : Type of experiment: rat liver microsomes. The amount of 6-gingerol present in extract of Zingiber officinal, Trikatumarketed formulation and Trikatu laboratory formulation was estimated to be about 6.21+/-1.03%, 5.3+/-1.21% and 4.95+/-2.34% (w/w), respectively. Piperine was found to be 7.31+/-2.36% (Piper longum), 8.41+/-2.54% (Piper nigrum), 7.89+/-2.12% (Trikatu marketed formulation) and 6.70+/-2.13% (w/w) (Trikatu laboratory formulation).

Part Used : เหง้า
Activity : CYTOCHROME P-450 INHIBITION
Solvent/Active Compound : 6-gingerol DMSO
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 6-gingerol DMSO 10 micrograms/mL
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Result : Positive
Remark : Results: Extract of the formulations and its ingredients had higher solubility in DMSO than ethanol. It illustrated the highest percentage of inhibition: 37.54+/-3.12% (Trikatu marketed formulation), 35.12+/-2.31% (Trikatu laboratory formulation), 33.23+/-2.56% (6-gingerol), 31.36+/-3.42% (piperine), 17.35+/+1.50% (Zingiber officinale), 20.21+/-1.86% (Piper longum), and 16.67+/-2.83% (Piper nigrum). Lowest inhibition (24.81+/-2.57% and 26.38+/-2.57%) of piperine and 6-gingerol was observed with ethanol.
Note : Type of experiment: rat liver microsomes. The amount of 6-gingerol present in extract of Zingiber officinal, Trikatumarketed formulation and Trikatu laboratory formulation was estimated to be about 6.21+/-1.03%, 5.3+/-1.21% and 4.95+/-2.34% (w/w), respectively. Piperine was found to be 7.31+/-2.36% (Piper longum), 8.41+/-2.54% (Piper nigrum), 7.89+/-2.12% (Trikatu marketed formulation) and 6.70+/-2.13% (w/w) (Trikatu laboratory formulation).

Part Used : เหง้า
Activity : CYTOCHROME P-450 INHIBITION
Solvent/Active Compound : Trikatu laboratory formulation / Ethanol
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 100 micrograms/mL
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Result : Positive
Remark : Results: Extract of the formulations and its ingredients had higher solubility in DMSO than ethanol. It illustrated the highest percentage of inhibition: 37.54+/-3.12% (Trikatu marketed formulation), 35.12+/-2.31% (Trikatu laboratory formulation), 33.23+/-2.56% (6-gingerol), 31.36+/-3.42% (piperine), 17.35+/+1.50% (Zingiber officinale), 20.21+/-1.86% (Piper longum), and 16.67+/-2.83% (Piper nigrum). Lowest inhibition (24.81+/-2.57% and 26.38+/-2.57%) of piperine and 6-gingerol was observed with ethanol.
Note : Type of experiment: rat liver microsomes. The amount of 6-gingerol present in extract of Zingiber officinal, Trikatumarketed formulation and Trikatu laboratory formulation was estimated to be about 6.21+/-1.03%, 5.3+/-1.21% and 4.95+/-2.34% (w/w), respectively. Piperine was found to be 7.31+/-2.36% (Piper longum), 8.41+/-2.54% (Piper nigrum), 7.89+/-2.12% (Trikatu marketed formulation) and 6.70+/-2.13% (w/w) (Trikatu laboratory formulation).

Part Used : ผล
Activity : CYTOCHROME P-450 INHIBITION
Solvent/Active Compound : Trikatu laboratory formulation / Ethanol
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 100 micrograms/mL
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Result : Positive
Remark : Results: Extract of the formulations and its ingredients had higher solubility in DMSO than ethanol. It illustrated the highest percentage of inhibition: 37.54+/-3.12% (Trikatu marketed formulation), 35.12+/-2.31% (Trikatu laboratory formulation), 33.23+/-2.56% (6-gingerol), 31.36+/-3.42% (piperine), 17.35+/+1.50% (Zingiber officinale), 20.21+/-1.86% (Piper longum), and 16.67+/-2.83% (Piper nigrum). Lowest inhibition (24.81+/-2.57% and 26.38+/-2.57%) of piperine and 6-gingerol was observed with ethanol.
Note : Type of experiment: rat liver microsomes. The amount of 6-gingerol present in extract of Zingiber officinal, Trikatumarketed formulation and Trikatu laboratory formulation was estimated to be about 6.21+/-1.03%, 5.3+/-1.21% and 4.95+/-2.34% (w/w), respectively. Piperine was found to be 7.31+/-2.36% (Piper longum), 8.41+/-2.54% (Piper nigrum), 7.89+/-2.12% (Trikatu marketed formulation) and 6.70+/-2.13% (w/w) (Trikatu laboratory formulation).

Part Used : เหง้า
Activity : CYTOCHROME P-450 INHIBITION
Solvent/Active Compound : Trikatu laboratory formulation / DMSO
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 100 micrograms/mL
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Result : Positive
Remark : Results: Extract of the formulations and its ingredients had higher solubility in DMSO than ethanol. It illustrated the highest percentage of inhibition: 37.54+/-3.12% (Trikatu marketed formulation), 35.12+/-2.31% (Trikatu laboratory formulation), 33.23+/-2.56% (6-gingerol), 31.36+/-3.42% (piperine), 17.35+/+1.50% (Zingiber officinale), 20.21+/-1.86% (Piper longum), and 16.67+/-2.83% (Piper nigrum). Lowest inhibition (24.81+/-2.57% and 26.38+/-2.57%) of piperine and 6-gingerol was observed with ethanol.
Note : Type of experiment: rat liver microsomes. The amount of 6-gingerol present in extract of Zingiber officinal, Trikatumarketed formulation and Trikatu laboratory formulation was estimated to be about 6.21+/-1.03%, 5.3+/-1.21% and 4.95+/-2.34% (w/w), respectively. Piperine was found to be 7.31+/-2.36% (Piper longum), 8.41+/-2.54% (Piper nigrum), 7.89+/-2.12% (Trikatu marketed formulation) and 6.70+/-2.13% (w/w) (Trikatu laboratory formulation).


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