| Synonym |
| Thai / English name |
Part Used : เหง้าActivity : PLATELET AGGREGATION INHIBITIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12N(Treatment) : 12Sex : MaleAge : 20-36 yrsRoute : Oral administrationDose/Conc.(herb) : 3 tablets x 3 times dailyDuration : 1 week with at least 14-day washoutType of interaction : PharmacodynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : The mean ratios of the AUCO-168 of INR were 0.93 (0.82-1.05) following treatment with ginkgo and 1.03 (0.90-1.15) for ginger treatment. These data suggest there is no significant effect of these herbs on warfarin pharmacodynamics. Neither ginkgo nor ginger alone affected baseline INR or ex vivo platelet aggregation in response to arachidonic acid.Note : Each ginger tablet containing 0.4 g of ginger rhizome powder Each Gingko tablet equivalent to 2 g of Ginkgo biloba leaf (9.6 mg of ginkgo flavonglycosides, 2.4 mg of ginkgolides and bilobalide)
Part Used : เหง้าActivity : PLATELET AGGREGATION INHIBITIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 12N(Treatment) : 12Sex : MaleAge : 20-36 yrsRoute : Oral administrationDose/Conc.(herb) : 3 tablets x 3 times dailyDuration : 1 week with at least 14-day washoutType of interaction : PharmacodynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : The mean ratios of the AUCO-168 of INR were 0.93 (0.82-1.05) following treatment with ginkgo and 1.03 (0.90-1.15) for ginger treatment. These data suggest there is no significant effect of these herbs on warfarin pharmacodynamics. Neither ginkgo nor ginger alone affected baseline INR or ex vivo platelet aggregation in response to arachidonic acid.Note : Each ginger tablet containing 0.4 g of ginger rhizome powder Each Gingko tablet equivalent to 2 g of Ginkgo biloba leaf (9.6 mg of ginkgo flavonglycosides, 2.4 mg of ginkgolides and bilobalide)
Part Used : เหง้าActivity : PLATELET AGGREGATION INHIBITIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 20N(Treatment) : 20Sex : Both sexAge : 25-60 yrRoute : Oral administrationDose/Conc.(herb) : 1 g of ginger with 10 mg nifedipine, twice dailyDuration : 1 weekType of interaction : PharmacodynamicsInteraction with drug : NifedipineDose/Conc.(drug) : -Result : PositiveRemark : Phase I: the normal volunteers were administered both ginger and nifedipine in combination, it was observed that the higher percentage inhibition of platelet aggregation induced by collagen, ADP and epinephrine were 79.8%, 75.2% and 69.3%, resp. The results indicated that ginger could potentiate the anti-platelet aggregation of nifedipine.Note : Thie study departed into 2 phases. Phase I: normal volunteer, Phase II: hypertensive patient (10) - All results were similar but higher in phase II of the study.
Part Used : เหง้าActivity : PLATELET AGGREGATION INHIBITIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 20N(Treatment) : 20Sex : Both sexAge : 35-60 yrRoute : Oral administrationDose/Conc.(herb) : 1 g of ginger with 10 mg nifedipine, twice dailyDuration : 1 weekType of interaction : PharmacodynamicsInteraction with drug : NifedipineDose/Conc.(drug) : -Result : PositiveRemark : Phase I: study in hypertensive patients showed that the percentage of inhibition of values with the three agonist was higher (64.2%, 63.8% and 61.1%, resp.) after the treatment with the combination of nifedipone and ginger. The results indicated that ginger could potentiate the anti-platelet aggregation of nifedipine.Note : Thie study departed into 2 phases. Phase I: normal volunteer, Phase II: hypertensive patient (10) - All results were similar but higher in phase II of the study.
Part Used : ไม่ระบุActivity : PLATELET AGGREGATION INHIBITIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 10N(Treatment) : 10Sex : Both sexAge : 25-60 yearsRoute : Oral administrationDose/Conc.(herb) : 1 gDuration : 7 daysType of interaction : PharmacodynamicsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Subjects: normal volunteers Results: The percentage of platelet aggregation with collagen, ADP and epinephrine was 44.1%, 44.5% and 42.1% in normal subjects. After administration of ginger alone, the percentages of inhibition of platelet aggregation induced by collagen, ADP and epinephrine were 35.2%, 37.8%, 35.9% respectively.
Part Used : ไม่ระบุActivity : PLATELET AGGREGATION INHIBITIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 10N(Treatment) : 10Sex : Both sexAge : 25-60 yearsRoute : Oral administrationDose/Conc.(herb) : 1 gDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : NifedipineDose/Conc.(drug) : 10 mgResult : PositiveRemark : Subjects: normal volunteers Results: When the volunteers were administered both ginger and nifedipine in combination, it was observed that the percentage inhibition of platelet aggregation induced by collagen, ADP and epinephrine were 79.8%, 75.2%, 69.3% respectively. These results suggested that ginger and nifedipine possessed synergistic effect on anti-platelet aggregation in normal volunteer.
Part Used : ไม่ระบุActivity : PLATELET AGGREGATION INHIBITIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : 10N(Treatment) : 10Sex : Both sexAge : 35-60 yearsRoute : Oral administrationDose/Conc.(herb) : 1 gDuration : 7 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : NifedipineDose/Conc.(drug) : 10 mgResult : PositiveRemark : Subjects: hypertensive patients Results: After the treatment of the combination of nifedipine and ginger, the percentage of inhibition values with the three agonist were 64.2%, 63.8%, 61.1% respectively in hypertensive patients.
