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Thai / English name |
Part Used : เหง้าActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : waterType of experiment : in vivoType of animal : rabbitType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1 ml/kg dailyDuration : 3 days with 2-week washout periodType of interaction : PharmacokineticsInteraction with drug : MetronidazoleDose/Conc.(drug) : -Result : PositiveRemark : The peak (Cmax) in the plasma concentration-time curve of metronidazole plus ginger occurred about 4h while metronidazole alone was in 2h post administration, indicated that ginger may have caused delay in the rate of absorption of oral metronidazole. The metronidazole clearance and the elimination rate were reduced in metronidazole plus ginger group (phase II)Note : The study design into 2 phases. In phase I, rabbits were given only metronidazole and phase II, the rabbits were given 1 ml/kg of ginger extract per oral daily for 3 days and immediately given 3 mg/kg metronidazole per oral on the third day.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : waterType of experiment : in vivoType of animal : rabbitType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 1 ml/kg dailyDuration : 3 days with 2-week washout periodType of interaction : PharmacokineticsInteraction with drug : MetronidazoleDose/Conc.(drug) : -Result : PositiveRemark : The peak (Cmax) in the plasma concentration-time curve of metronidazole plus ginger occurred about 4h while metronidazole alone was in 2h post administration, indicated that ginger may have caused delay in the rate of absorption of oral metronidazole. The metronidazole clearance and the elimination rate were reduced in metronidazole plus ginger group (phase II)Note : The study design into 2 phases. In phase I, rabbits were given only metronidazole and phase II, the rabbits were given 1 ml/kg of ginger extract per oral daily for 3 days and immediately given 3 mg/kg metronidazole per oral on the third day.