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Part Used : รำActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : -Result : PositiveRemark : Rice bran was found to be a better adsorbent than wheat bran. Basic drugs were adsorbed to a much larger extent compare to acidic drugs. Amongst acidic drugs adsorption of paracetamol was highest. Amongst basic drugs adsorption of promethazine was lowest.Note : Data incomplete
Part Used : รำActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Promethazine*/Proazamine/DipherganDose/Conc.(drug) : -Result : PositiveRemark : Rice bran was found to be a better adsorbent than wheat bran. Basic drugs were adsorbed to a much larger extent compare to acidic drugs. Amongst acidic drugs adsorption of paracetamol was highest. Amongst basic drugs adsorption of promethazine was lowest.Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : wheat germ agglutinin (WGA)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Monensin*/Monensic acidDose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: human leukemia cell lines, Molt3 and K562 Results: In Molt3 but not in K562 cells, WGA cytotoxicity could be potentiated 66-200 fold by 50 nM monensin, a carboxylic ionophore that perturbs the intracellular trafficking of endocytosed mols. Synergism between the cytotoxic activities of WGA and monensin was demonstrated in Molt3 cells by comparing non toxic, or slightly toxic, doses of WGA and monensin alone or in combinaiton.Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : wheat germ agglutininType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 50 IU/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : InsulinDose/Conc.(drug) : -Result : PositiveRemark : The insulin solid lipid nanoparticles (SLNs) promote the absorption of insulin taken orally, and wheat germ agglutinin modified SLNs (WGA-SLNs) promote the absorption of insulin taken orally due to the specific-site combination on GI cell membrane.Note : Data incomplete
Part Used : รำActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : 4 weeksType of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : NegativeRemark : Subjects: geriatric in-patients treated with either combination (16 with wheat bran + digoxin, 14 with ispaghula + digoxin). Results: neither wheat bran not the ispaghula formulation has any clinically relevant influence on therapeutic digoxin levels in geriatric patients.Note : Data incomplete
Part Used : รำActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 7N(Treatment) : 7Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 35 gDuration : 168 h after the administration of phenprocoumonType of interaction : PharmacokineticsInteraction with drug : Phenprocoumon*/PhenprocoumarolDose/Conc.(drug) : -Result : PositiveRemark : Following the ingestion of wheat bran, a decreased absorption rate for phenprocoumon but no decrease in overall bioavailability was observed. In addition, a decrease in total body clearance of phenprocoumon and an increase in the free plasma fraction of phenprocoumon, resulting in decreased free drug clearance, was seen after wheat bran administration.Note : Data incomplete.
