ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : รำ

Activity : EFFECTS ON PHARMACOKINETIC

Solvent/Active Compound : -

Type of experiment : human

Type of animal : -

Type of study : Cross over

N(Total) : 7

N(Treatment) : 7

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : 35 g

Duration : 168 h after the administration of phenprocoumon

Type of interaction : Pharmacokinetics

Interaction with drug : Phenprocoumon*/Phenprocoumarol

Dose/Conc.(drug) : -

Result : Positive

Remark : Following the ingestion of wheat bran, a decreased absorption rate for phenprocoumon but no decrease in overall bioavailability was observed. In addition, a decrease in total body clearance of phenprocoumon and an increase in the free plasma fraction of phenprocoumon, resulting in decreased free drug clearance, was seen after wheat bran administration.

Note : Data incomplete.

---