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GRAMINEAE (POACEAE) Zea mays L.

Synonym

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Thai / English name

ข้าวโพด*

[1-2] of 2 article(s) found

หน้า 1

[1] CHANGES IN LIVER MICROSOMAL CYTOCHROME P-450 INDUCED BY DIETARY PROTEINS AND LIPID MATERIAL.
FIELDING AM,HUGHES RE
BIOCHEM PHARMACOL 1976 Vol.25(16),1916-7 002459 [Abstract]

Part Used : น้ำมันจากเมล็ด
Activity : CYTOCHROME P-450 LEVEL INCREASE

Solvent/Active Compound : aged (oxidized) corn oil

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: When aged (oxidized) corn oil was used instead of fresh corn oil in the casein diet, the cytochrome P450 content was increased (from 43 to 105 nmole/liver).

Note : Different types of dietary proteins altered the liver microsomal content of cytochromes P450 and b5 to different extents and the effects were apparently unrelated to the comparative biological values of the proteins. Data incomeplete.

[2] EFFECTS OF LIPID INGESTION ON THE INDUCTION OF DRUG METABOLIZING ENZYMES OF NUCLEAR ENVELOPE AND MICROSOMES BY PHENOBARBITAL.
CHENG K-C,RAGLAND WL,WADE AE
J ENVIRON PATHOL TOXICOL 1980 Vol.4(1),219-35 002468 [Abstract]

Part Used : น้ำมันจากเมล็ด
Activity : CYTOCHROME P-450 LEVEL INCREASE

Solvent/Active Compound : corn oil

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 10% corn oil-containing diets

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark :

Note : Result: Cytochrome P-450 levels in corn oil-fed rats were significantly higher than in rats fed the fat-free diet. A significantly higher 'concentration' of cytochrome P-450 available for CO binding was observed in rats fed the 10% corn oil diet than in rats fed fat-free diet. However, the increased concentration of cytochrome P-450 measured by CO binding was not supported by direct measurement of proteins in the molecular weight range of cytochrome P-450 using quatitative fluorescence gel electrophoresis. Dietary supplementation with polyunsaturated fatty acids may provide a lipid environment which modulated cytochrome P-450 to a conformation more accessible to the binding of CO, drugs, and other xenobiotics. Data incomplete.

หน้า 1

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