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Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : n-6 linoleinc acid-rich corn oil (C-oil)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10% corn oil plus 40 ppm indomethacin in their drinking waterDuration : 32 weeksType of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : indomethacin 40 ppm in the drinking waterResult : EquivocalRemark : Result: The serum PGE2 levels tended to decrease on treatment wih indomethacin (IM) but were increased by corn oil compared with the control level. These latter increases tended to be diminished to the control level with the addition of IM (Corn oil +IM). However, no significant differences were observed between the values.Note : The animals were given a combined treatment comprised of a single i.p. administration of 100 mg/kg body weight N-diethylnitrosamine (DEN) at the commencement of the study, four i.p. administrations of 20 mg/kg body wt. N-methyl-nitrosourea (MNU) (on days 3, 6, 9 and 12), four s.c. administrations of 40 mg/kg body wt. 1,2-dimethylhydrazine (DMH) (on days 14, 18, 22 and 29), 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in their drinking water for 2 weeks and 0.1% N-nitrosobis (2-hydroxypropyl) amine (DHPN) in their drinking water for 2 weeks during the initial four week period for wide spectrum initiation. Three days after completion of carcinogen exposure, test diets were given to the animals.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : maize polyamine oxidase (MPAO)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : 5 daysType of interaction : PharmacodynamicsInteraction with drug : Imipenem*/Imipemide/Imipenemum/N-formimidoylthienamycin/TienamycinDose/Conc.(drug) : Etoposide 0 - 100 microMResult : PositiveRemark : Result: Recombinant maize polyamine oxidase (MPAO) expression in the 4.31 MPAOnuc-MCF7 cells conferred higher growth sensitivity to 24 h treatment with etoposide, a widely used antineoplastic drug which inhibits topoisomerase II at the strand rejoining step resulting in single and double strand breaks in DNA. Data from a dose-response analysis have indeed showed that the -Dox MPAOnuc-MCF7 cells are characterised by an IC50 value (etoposide concentration at which 50% inhibition of cell growth is observed) for etoposide of 22.9+/-0.5 microM which is significantly lower than that of the +Dox MPAOnuc-MCF7 cells (IC50 = 42.0+/- 0.3 microM) (P<0.05).
Part Used : น้ำมันจากเมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : corn oil (linoleic acid)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : Feeding diets with 15% corn oil + 6% protein* (Group 1) for six weeks. After the feeding period, liver injury was induced by injecting either with 600 mg/kg body weight acetaminophen suspended in gum arabic-based vehicle.Duration : 6 weeksType of interaction : PharmacodynamicsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : Acetaminophen 600 mg/kg body weightResult : PositiveRemark : Result: glutathione (GSH) level was significantly lower in only group fed 15% corn oil with 6 g/100 g protein among acetaminophen-treated groups, activities of Glutamate-pyruvate transaminase (GPT) and glutamate-oxaloacetate transaminase (GOT) were significantly elevated in all groups except the one fed beef tallow with 20 g/100 g protein, suggesting low protein might exacerbate drug-induced hepatotoxicity.Note : The feeding regimens changed the ratio of 18:2n-6 to oleic acid (18:1n-9) in total liver lipids approximately five-fold, and produced modest changes in arachidonic acid (20:4n-6). Conclusion: Diets with high 18:2n-6 promote acetaminophen-induced liver injury compared to diets with more saturated fatty acids (SFA). In addition, protein restriction appeared to exacerbate the liver injury. *Dose: protein = casein:lactoalbumin (1:1)
Part Used : น้ำมันจากเมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : corn oil (linoleic acid)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : Feeding diets with 15% corn oil + 20% protein* (Group 2) for six weeks. After the feeding period, liver injury was induced by injecting either with 600 mg/kg body weight acetaminophen suspended in gum arabic-based vehicle.Duration : 6 weeksType of interaction : PharmacodynamicsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : Acetaminophen 600 mg/kg body weightResult : PositiveRemark : Result: Activities of Glutamate-pyruvate transaminase (GPT) and glutamate-oxaloacetate transaminase (GOT) were significantly elevated in all groups except the one fed beef tallow with 20 g/100 g protein, suggesting low protein might exacerbate drug-induced hepatotoxicity.Note : The feeding regimens changed the ratio of 18:2n-6 to oleic acid (18:1n-9) in total liver lipids approximately five-fold, and produced modest changes in arachidonic acid (20:4n-6). Conclusion: Diets with high 18:2n-6 promote acetaminophen-induced liver injury compared to diets with more saturated fatty acids (SFA). In addition, protein restriction appeared to exacerbate the liver injury. *Dose: protein = casein:lactoalbumin (1:1)
Part Used : น้ำมันจากเมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : corn oil (linoleic acid)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : Feeding diets with 14% beef tallow + 1% corn oil + 6% protein* (Group 3) for six weeks. After the feeding period, liver injury was induced by injecting either with 600 mg/kg body weight acetaminophen suspended in gum arabic-based vehicle.Duration : 6 weeksType of interaction : PharmacodynamicsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : Acetaminophen 600 mg/kg body weightResult : PositiveRemark : Result: Activities of Glutamate-pyruvate transaminase (GPT) and glutamate-oxaloacetate transaminase (GOT) were significantly elevated in all groups except the one fed beef tallow with 20 g/100 g protein, suggesting low protein might exacerbate drug-induced hepatotoxicity.Note : The feeding regimens changed the ratio of 18:2n-6 to oleic acid (18:1n-9) in total liver lipids approximately five-fold, and produced modest changes in arachidonic acid (20:4n-6). Conclusion: Diets with high 18:2n-6 promote acetaminophen-induced liver injury compared to diets with more saturated fatty acids (SFA). In addition, protein restriction appeared to exacerbate the liver injury. *Dose: protein = casein:lactoalbumin (1:1)
Part Used : น้ำมันจากเมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : corn oil (linoleic acid)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : Feeding diets with 14% beef tallow + 1% corn oil + 20% protein* (Group 4) for six weeks. After the feeding period, liver injury was induced by injecting either with 600 mg/kg body weight acetaminophen suspended in gum arabic-based vehicle.Duration : 6 weeksType of interaction : PharmacodynamicsInteraction with drug : Paracetamol*/Acetaminophen/APAP/N-acetyl-p-aminophenolDose/Conc.(drug) : Acetaminophen 600 mg/kg body weightResult : EquivocalRemark :Note : The feeding regimens changed the ratio of 18:2n-6 to oleic acid (18:1n-9) in total liver lipids approximately five-fold, and produced modest changes in arachidonic acid (20:4n-6). Conclusion: Diets with high 18:2n-6 promote acetaminophen-induced liver injury compared to diets with more saturated fatty acids (SFA). In addition, protein restriction appeared to exacerbate the liver injury. *Dose: protein = casein:lactoalbumin (1:1)
Part Used : น้ำมันจากเมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : corn oilType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Indomethacin*/IndometacinDose/Conc.(drug) : -Result : PositiveRemark :Note : Result: When indomethacin given with sunflower, corn and olive oils reduced paw edema induced by carrageenan by 79.5%, 74.0% and 60.5%, whereas individual indomethacin and diclofenac reduced paw edema by 56.2% and 50.7%, resp. Besides, the administration of indomethacin together with the vegetable oils and alpha-tocopherol did not cause a statistically significant gastric damage in rats (P > 0.05). However, indomethacin caused statistically significant gastric lesions as compared with untreated rats (P < 0.05). These results suggest that indomethacin as well as other NSAIDs do not have any adverse effect on the gastrointestinal tract when they are used together with vetgetable oils and vitamin E or as the preparations of the oils.
